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Rabbit Anti-GTPBP4 Recombinant Antibody (CBLG1-3043) (CBMAB-G5753-LY)

This product is antibody recognizes GTPBP4. The antibody CBLG1-3043 immunoassay techniques such as: WB.
See all GTPBP4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBLG1-3043
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GTP binding protein 4
Entrez Gene ID
23560
UniProt ID
Q9BZE4
Alternative Names
GTP Binding Protein 4; Chronic Renal Failure Gene Protein; G Protein-Binding Protein CRFG; GTP-Binding Protein NGB; CRFG; NOG1; Nucleolar GTP-Binding Protein 1; GTP-Binding Protein; NGB;
Function
Involved in the biogenesis of the 60S ribosomal subunit.
Biological Process
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: Ensembl
Negative regulation of cell-cell adhesion Source: HGNC-UCL
Negative regulation of cell migration Source: HGNC-UCL
Negative regulation of cell population proliferation Source: HGNC-UCL
Negative regulation of collagen binding Source: HGNC-UCL
Negative regulation of DNA replication Source: HGNC-UCL
Negative regulation of protein ubiquitination Source: HGNC-UCL
Osteoblast differentiation Source: UniProtKB
Protein stabilization Source: HGNC-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: HGNC-UCL
Cellular Location
Nucleolus

Zhou, Q., Yin, Y., Yu, M., Gao, D., Sun, J., Yang, Z., ... & Ren, N. (2022). GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism. Redox Biology, 56, 102458.

Wu, J., Chen, G., Wang, W., Yang, Y., Yuan, Y., Shang, A., ... & Wang, L. (2022). GTPBP4: A New Therapeutic Target Gene Promotes Tumor Progression in Non-Small Cell Lung Cancer via EMT. Journal of Oncology, 2022.

Hu, Y., Xie, J., Chen, L., Tang, Q., Wei, W., Lin, W., ... & Ji, J. (2022). Integrated analysis of genomic and transcriptomic profiles identified the role of GTP binding protein-4 (GTPBP4) in breast cancer. Frontiers in Pharmacology, 13.

Chen, J., Zhang, J., & Zhang, Z. (2021). Upregulation of GTPBP4 promotes the proliferation of liver cancer cells. Journal of Oncology, 2021.

Zhang, N., Shen, H., Huang, S., Wang, F., Liu, H., Xie, F., ... & Chen, X. (2021). LncRNA FGD5-AS1 functions as an oncogene to upregulate GTPBP4 expression by sponging miR-873-5p in hepatocellular carcinoma. European Journal of Histochemistry: EJH, 65(4).

Zhang, Z., Wang, J., Mao, J., Li, F., Chen, W., & Wang, W. (2020). Determining the clinical value and critical pathway of GTPBP4 in lung adenocarcinoma using a bioinformatics strategy: a study based on datasets from the cancer genome atlas. BioMed Research International, 2020.

Li, L., Pang, X., Zhu, Z., Lu, L., Yang, J., Cao, J., & Fei, S. (2018). GTPBP4 promotes gastric cancer progression via regulating P53 activity. Cellular Physiology and Biochemistry, 45(2), 667-676.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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