Sign in or Register   Sign in or Register
  |  

Rabbit Anti-HAPLN1 Recombinant Antibody (CBFYH-0690) (CBMAB-H1579-FY)

This product is rabbit antibody that recognizes HAPLN1. The antibody CBFYH-0690 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all HAPLN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Zebrafish
Clone
CBFYH-0690
Antibody Isotype
IgG
Application
WB, IHC-P, IF

Basic Information

Immunogen
Recombinant protein
Specificity
Human, Mouse, Rat, Zebrafish
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS, pH 7.4, 1% BSA, 40% glycerol
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Hyaluronan And Proteoglycan Link Protein 1
Introduction
HAPLN1 (Hyaluronan And Proteoglycan Link Protein 1) is a Protein Coding gene. Diseases associated with HAPLN1 include Juvenile Rheumatoid Arthritis and Cerebral Creatine Deficiency Syndrome 3. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent and hyaluronic acid binding. An important paralog of this gene is HAPLN3.
Entrez Gene ID
Human1404
Mouse12950
Rat29331
UniProt ID
HumanP10915
MouseQ9QUP5
RatP03994
Alternative Names
Hyaluronan And Proteoglycan Link Protein 1; Cartilage-Linking Protein 1; Proteoglycan Link Protein; Cartilage Link Protein; Cartilage-Link Protein; CRTL1; Cartilage Linking Protein 1; CRT1
Function
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
Biological Process
Cell adhesion Source: InterPro
Central nervous system development Source: GO_Central
Skeletal system development Source: GO_Central
Cellular Location
Extracellular matrix

Wiedmann, L., De Angelis Rigotti, F., Vaquero-Siguero, N., Donato, E., Espinet, E., Moll, I., ... & Rodriguez-Vita, J. (2023). HAPLN1 potentiates peritoneal metastasis in pancreatic cancer. Nature Communications, 14(1), 2353.

Zhang, T., Li, X., He, Y., Wang, Y., Shen, J., Wang, S., ... & Shen, L. (2022). Cancer-associated fibroblasts-derived HAPLN1 promotes tumour invasion through extracellular matrix remodeling in gastric cancer. Gastric Cancer, 1-14.

Sun, J., Peterson, E. A., Wang, A. Z., Ou, J., Smith, K. E., Poss, K. D., & Wang, J. (2022). hapln1 defines an epicardial cell subpopulation required for cardiomyocyte expansion during heart morphogenesis and regeneration. Circulation, 146(1), 48-63.

Kuźnik-Trocha, K., Winsz-Szczotka, K., Lachór-Motyka, I., Dąbkowska, K., Wojdas, M., Olczyk, K., & Komosińska-Vassev, K. (2022). The effects of TNF-α inhibition on the metabolism of cartilage: Relationship between KS, HA, HAPLN1 and ADAMTS4, ADAMTS5, TOS and TGF-β1 plasma concentrations in patients with juvenile idiopathic arthritis. Journal of Clinical Medicine, 11(7), 2013.

Evanko, S. P., Gooden, M. D., Kang, I., Chan, C. K., Vernon, R. B., & Wight, T. N. (2020). A role for HAPLN1 during phenotypic modulation of human lung fibroblasts in vitro. Journal of Histochemistry & Cytochemistry, 68(11), 797-811.

Chen, Y., Qiu, F., Yu, B., Chen, Y., Zuo, F., Zhu, X., ... & Xiao, C. (2020). Metformin, an AMPK activator, inhibits activation of FLSs but promotes HAPLN1 secretion. Molecular Therapy-Methods & Clinical Development, 17, 1202-1214.

Ecker, B. L., Kaur, A., Douglass, S. M., Webster, M. R., Almeida, F. V., Marino, G. E., ... & Weeraratna, A. T. (2019). Age-related changes in HAPLN1 increase lymphatic permeability and affect routes of melanoma metastasis. Cancer discovery, 9(1), 82-95.

Huynh, M., Pak, C., Markovina, S., Callander, N. S., Chng, K. S., Wuerzberger-Davis, S. M., ... & Miyamoto, S. (2018). Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-κB activity and increases drug resistance in multiple myeloma. Journal of Biological Chemistry, 293(7), 2452-2465.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-HAPLN1 Recombinant Antibody (CBFYH-0690)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare