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Rat Anti-HAPLN1 Recombinant Antibody (CBYY-C2529) (CBMAB-C3970-YY)

This product is rat antibody that recognizes HAPLN1. The antibody CBYY-C2529 can be used for immunoassay techniques such as: ELISA, IHC, IP
See all HAPLN1 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
CBYY-C2529
Antibody Isotype
IgG1
Application
ELISA, IHC, IP

Basic Information

Immunogen
Human cartilage derived COMP
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Tissue culture supernatant
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Hyaluronan And Proteoglycan Link Protein 1
Entrez Gene ID
1404
UniProt ID
P10915
Alternative Names
Interleukin 18 Receptor 1
Function
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
Biological Process
Cell adhesion Source: InterPro
Central nervous system development Source: GO_Central
Skeletal system development Source: GO_Central
Cellular Location
Extracellular matrix

Wiedmann, L., De Angelis Rigotti, F., Vaquero-Siguero, N., Donato, E., Espinet, E., Moll, I., ... & Rodriguez-Vita, J. (2023). HAPLN1 potentiates peritoneal metastasis in pancreatic cancer. Nature Communications, 14(1), 2353.

Zhang, T., Li, X., He, Y., Wang, Y., Shen, J., Wang, S., ... & Shen, L. (2022). Cancer-associated fibroblasts-derived HAPLN1 promotes tumour invasion through extracellular matrix remodeling in gastric cancer. Gastric Cancer, 1-14.

Sun, J., Peterson, E. A., Wang, A. Z., Ou, J., Smith, K. E., Poss, K. D., & Wang, J. (2022). hapln1 defines an epicardial cell subpopulation required for cardiomyocyte expansion during heart morphogenesis and regeneration. Circulation, 146(1), 48-63.

Kuźnik-Trocha, K., Winsz-Szczotka, K., Lachór-Motyka, I., Dąbkowska, K., Wojdas, M., Olczyk, K., & Komosińska-Vassev, K. (2022). The effects of TNF-α inhibition on the metabolism of cartilage: Relationship between KS, HA, HAPLN1 and ADAMTS4, ADAMTS5, TOS and TGF-β1 plasma concentrations in patients with juvenile idiopathic arthritis. Journal of Clinical Medicine, 11(7), 2013.

Evanko, S. P., Gooden, M. D., Kang, I., Chan, C. K., Vernon, R. B., & Wight, T. N. (2020). A role for HAPLN1 during phenotypic modulation of human lung fibroblasts in vitro. Journal of Histochemistry & Cytochemistry, 68(11), 797-811.

Chen, Y., Qiu, F., Yu, B., Chen, Y., Zuo, F., Zhu, X., ... & Xiao, C. (2020). Metformin, an AMPK activator, inhibits activation of FLSs but promotes HAPLN1 secretion. Molecular Therapy-Methods & Clinical Development, 17, 1202-1214.

Ecker, B. L., Kaur, A., Douglass, S. M., Webster, M. R., Almeida, F. V., Marino, G. E., ... & Weeraratna, A. T. (2019). Age-related changes in HAPLN1 increase lymphatic permeability and affect routes of melanoma metastasis. Cancer discovery, 9(1), 82-95.

Huynh, M., Pak, C., Markovina, S., Callander, N. S., Chng, K. S., Wuerzberger-Davis, S. M., ... & Miyamoto, S. (2018). Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-κB activity and increases drug resistance in multiple myeloma. Journal of Biological Chemistry, 293(7), 2452-2465.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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