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Mouse Anti-HTR1B Recombinant Antibody (CBLQH-011) (CBMAB-2055CQ)

This product is a mouse monoclonal antibody that recognizes HTR1B. The antibody CBLQH-011 can be used for immunoassay techniques such as: IHC.
See all HTR1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLQH-011
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human 5HT1B, Met1-Ser390
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5-hydroxytryptamine receptor 1B
Introduction
The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.
Entrez Gene ID
3351
UniProt ID
P28222
Alternative Names
S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT-1B; 5-HT1DB; 5-HT-1D-beta
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: UniProtKB
Bone remodeling Source: Ensembl
Cellular response to alkaloid Source: UniProtKB
Cellular response to temperature stimulus Source: Ensembl
Cellular response to xenobiotic stimulus Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Drinking behavior Source: Ensembl
G protein-coupled receptor internalization Source: Ensembl
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Negative regulation of gamma-aminobutyric acid secretion Source: Ensembl
Negative regulation of serotonin secretion Source: UniProtKB
Negative regulation of synaptic transmission, GABAergic Source: Ensembl
Negative regulation of synaptic transmission, glutamatergic Source: Ensembl
Positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Presynaptic modulation of chemical synaptic transmission Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Regulation of behavior Source: InterPro
Regulation of dopamine secretion Source: Ensembl
Regulation of synaptic vesicle exocytosis Source: Ensembl
Response to cocaine Source: Ensembl
Response to ethanol Source: Ensembl
Response to mineralocorticoid Source: Ensembl
Vasoconstriction Source: InterPro
Cellular Location
Cell membrane
Topology
Extracellular: 1-49
Helical: 50-75
Cytoplasmic: 76-84
Helical: 85-110
Extracellular: 111-123
Helical: 124-145
Cytoplasmic: 146-165
Helical: 166-187
Extracellular: 188-205
Helical: 206-228
Cytoplasmic: 229-315
Helical: 316-336
Extracellular: 337-349
Helical: 350-371
Cytoplasmic: 372-390
PTM
Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.
Palmitoylated.

Palumbo, S., Mariotti, V., Vellucci, S., Antonelli, K., Anderson, N., Harenski, C., ... & Pellegrini, S. (2022). HTR1B genotype and psychopathy: Main effect and interaction with paternal maltreatment. Psychoneuroendocrinology, 144, 105861.

Xu, Z., Chen, Z., Shen, T., Chen, L., Tan, T., Gao, C., ... & Zhang, Z. (2022). The impact of HTR1A and HTR1B methylation combined with stress/genotype on early antidepressant efficacy. Psychiatry and Clinical Neurosciences, 76(2), 51-57.

Li, Y., Lu, Y., Xie, Q., Zeng, X., Zhang, R., Dang, W., ... & Zhang, J. (2022). Methylation and expression quantitative trait locus rs6296 in the HTR1B gene is associated with susceptibility to opioid use disorder. Psychopharmacology, 239(8), 2515-2523.

Sun, C., Qiu, Y., Ren, Q., Zhang, X., Cao, B., Zou, Y., ... & Wang, Y. (2021). Molecular cloning and functional characterization of three 5-HT receptor genes (HTR1B, HTR1E, and HTR1F) in chickens. Genes, 12(6), 891.

Cao, M., Shi, L., Peng, P., Han, B., Liu, L., Lv, X., ... & Sun, D. (2021). Determination of genetic effects and functional SNPs of bovine HTR1B gene on milk fatty acid traits. BMC genomics, 22(1), 1-10.

Grubor, M., Zivkovic, M., Sagud, M., Nikolac Perkovic, M., Mihaljevic-Peles, A., Pivac, N., ... & Svob Strac, D. (2020). HTR1A, HTR1B, HTR2A, HTR2C and HTR6 gene polymorphisms and extrapyramidal side effects in haloperidol-treated patients with schizophrenia. International Journal of Molecular Sciences, 21(7), 2345.

Xia, X., Ding, M., Xuan, J. F., Xing, J. X., Yao, J., Wu, X., & Wang, B. J. (2020). Functional polymorphisms and transcriptional analysis in the 5′ region of the human serotonin receptor 1B gene (HTR1B) and their associations with psychiatric disorders. BMC psychiatry, 20(1), 1-10.

Svob Strac, D., Nedic Erjavec, G., Nikolac Perkovic, M., Nenadic-Sviglin, K., Konjevod, M., Grubor, M., & Pivac, N. (2019). The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse. Neuropsychiatric Disease and Treatment, 339-347.

Xia, X., Ding, M., Xuan, J. F., Xing, J. X., Pang, H., Wang, B. J., & Yao, J. (2018). Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study. BMC psychiatry, 18, 1-11.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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