HTR1B

The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs.

Full Name

5-hydroxytryptamine receptor 1B

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: UniProtKB
Bone remodeling Source: Ensembl
Cellular response to alkaloid Source: UniProtKB
Cellular response to temperature stimulus Source: Ensembl
Cellular response to xenobiotic stimulus Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Drinking behavior Source: Ensembl
G protein-coupled receptor internalization Source: Ensembl
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Negative regulation of gamma-aminobutyric acid secretion Source: Ensembl
Negative regulation of serotonin secretion Source: UniProtKB
Negative regulation of synaptic transmission, GABAergic Source: Ensembl
Negative regulation of synaptic transmission, glutamatergic Source: Ensembl
Positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Presynaptic modulation of chemical synaptic transmission Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Regulation of behavior Source: InterPro
Regulation of dopamine secretion Source: Ensembl
Regulation of synaptic vesicle exocytosis Source: Ensembl
Response to cocaine Source: Ensembl
Response to ethanol Source: Ensembl
Response to mineralocorticoid Source: Ensembl
Vasoconstriction Source: InterPro

Cellular Location

Cell membrane

Topology

Extracellular: 1-49
Helical: 50-75
Cytoplasmic: 76-84
Helical: 85-110
Extracellular: 111-123
Helical: 124-145
Cytoplasmic: 146-165
Helical: 166-187
Extracellular: 188-205
Helical: 206-228
Cytoplasmic: 229-315
Helical: 316-336
Extracellular: 337-349
Helical: 350-371
Cytoplasmic: 372-390

PTM

Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.
Palmitoylated.