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Mouse Anti-IGSF11 Recombinant Antibody (CBYY-I2014) (CBMAB-I3184-YY)

This product is Mouse antibody that recognizes IGSF11. The antibody CBYY-I2014 can be used for immunoassay techniques such as: WB
See all IGSF11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I2014
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 23-241 of human IGSF11 (NP_689751)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Immunoglobulin Superfamily Member 11
Introduction
IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM).
Entrez Gene ID
152404
UniProt ID
Q5DX21
Alternative Names
Immunoglobulin Superfamily Member 11
Function
Functions as a cell adhesion molecule through homophilic interaction.
Biological Process
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Maintenance of protein location Source: Ensembl
Positive regulation of long-term synaptic potentiation Source: Ensembl
Positive regulation of mini excitatory postsynaptic potential Source: Ensembl
Regulation of growth Source: UniProtKB-KW
Cellular Location
Cell membrane
Topology
Extracellular: 23-241
Helical: 242-262
Cytoplasmic: 263-431
PTM
N-glycosylated.

Kim, H., Takegahara, N., & Choi, Y. (2023). IgSF11-mediated phosphorylation of pyruvate kinase M2 regulates osteoclast differentiation and prevents pathological bone loss. Bone Research, 11(1), 17.

Montag, D., Pelz, L., & Rathjen, F. G. (2023). Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test. Plos one, 18(1), e0280133.

Bougras-Cartron, G., Nadaradjane, A., Joalland, M. P., Lalier-Bretaudeau, L., Raimbourg, J., & Cartron, P. F. (2023). Adenosine Methylation Level of miR-125a-5p Promotes Anti-PD-1 Therapy Escape through the Regulation of IGSF11/VSIG3 Expression. Cancers, 15(12), 3188.

Pelz, L., Dossou, L., Kompier, N., Jüttner, R., Siemonsmeier, G., Meyer, N., ... & Rathjen, F. G. (2022). The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated astrocyte-astrocyte and ependymal cell-cell coupling. Biorxiv, 2022-06.

Tang, X. Y., Xiong, Y. L., Shi, X. G., Zhao, Y. B., Shi, A. P., Zheng, K. F., ... & Zhao, J. B. (2022). IGSF11 and VISTA: a pair of promising immune checkpoints in tumor immunotherapy. Biomarker Research, 10(1), 49.

Ghouzlani, A., Rafii, S., Karkouri, M., Lakhdar, A., & Badou, A. (2021). The promising IgSF11 immune checkpoint is highly expressed in advanced human gliomas and associates to poor prognosis. Frontiers in oncology, 10, 608609.

Hayano, Y., Ishino, Y., Hyun, J. H., Orozco, C. G., Steinecke, A., Potts, E., ... & Taniguchi, H. (2021). IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype. Science advances, 7(29), eabf1600.

Chen, B., Zhu, G., Yan, A., He, J., Liu, Y., Li, L., ... & Kee, K. (2021). IGSF11 is required for pericentric heterochromatin dissociation during meiotic diplotene. PLoS Genetics, 17(9), e1009778.

Kim, H., Takegahara, N., Walsh, M. C., Middleton, S. A., Yu, J., Shirakawa, J., ... & Choi, Y. (2020). IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95. Bone research, 8(1), 5.

Kim, H., Takegahara, N., Walsh, M. C., & Choi, Y. (2020). CD44 can compensate for IgSF11 deficiency by associating with the scaffold protein PSD-95 during osteoclast differentiation. International Journal of Molecular Sciences, 21(7), 2646.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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