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Mouse Anti-IL17C Recombinant Antibody (177114) (CBMAB-I0419-YY)

This product is Mouse antibody that recognizes IL17C. The antibody 177114 can be used for immunoassay techniques such as: WB, IHC, ICFC, CyTOF, ELISA
See all IL17C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
177114
Antibody Isotype
IgG2a
Application
WB, IHC, ICFC, CyTOF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 17C
Introduction
The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells.
Entrez Gene ID
27189
UniProt ID
Q9P0M4
Alternative Names
Interleukin 17C
Function
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Biological Process
Cell-cell signaling Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
Inflammatory response Source: ProtInc
Cellular Location
Secreted

Swedik, S., Madola, A., & Levine, A. (2021). IL-17C in human mucosal immunity: More than just a middle child. Cytokine, 146, 155641.

Lee, Y., Kim, S. J., Choo, J., Heo, G., Yoo, J. W., Jung, Y., ... & Im, E. (2020). miR-23a-3p is a key regulator of IL-17C-induced tumor angiogenesis in colorectal cancer. Cells, 9(6), 1363.

Nies, J. F., & Panzer, U. (2020). IL-17C/IL-17RE: emergence of a unique axis in TH17 biology. Frontiers in Immunology, 11, 341.

Wang, F., Yin, J., Lin, Y., Zhang, F., Liu, X., Zhang, G., ... & Qian, Y. (2020). IL-17C has a pathogenic role in kidney ischemia/reperfusion injury. Kidney International, 97(6), 1219-1229.

Lauffer, F., Jargosch, M., Baghin, V., Krause, L., Kempf, W., Absmaier‐Kijak, M., ... & Eyerich, K. (2020). IL‐17C amplifies epithelial inflammation in human psoriasis and atopic eczema. Journal of the European Academy of Dermatology and Venereology, 34(4), 800-809.

Ritzmann, F., Jungnickel, C., Vella, G., Kamyschnikow, A., Herr, C., Li, D., ... & Beisswenger, C. (2019). IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer. Scientific Reports, 9(1), 10353.

Guttman-Yassky, E., & Krueger, J. G. (2018). IL-17C: a unique epithelial cytokine with potential for targeting across the spectrum of atopic dermatitis and psoriasis. Journal of Investigative Dermatology, 138(7), 1467-1469.

Yamaguchi, S., Nambu, A., Numata, T., Yoshizaki, T., Narushima, S., Shimura, E., ... & Nakae, S. (2018). The roles of IL-17C in T cell-dependent and-independent inflammatory diseases. Scientific Reports, 8(1), 15750.

Vandeghinste, N., Klattig, J., Jagerschmidt, C., Lavazais, S., Marsais, F., Haas, J. D., ... & Steidl, S. (2018). Neutralization of IL-17C reduces skin inflammation in mouse models of psoriasis and atopic dermatitis. Journal of Investigative Dermatology, 138(7), 1555-1563.

Krohn, S., Nies, J. F., Kapffer, S., Schmidt, T., Riedel, J. H., Kaffke, A., ... & Panzer, U. (2018). IL-17C/IL-17 receptor E signaling in CD4+ T cells promotes TH17 cell-driven glomerular inflammation. Journal of the American Society of Nephrology: JASN, 29(4), 1210.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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