IL17C

The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
Full Name
Interleukin 17C
Function
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Biological Process
Cell-cell signaling Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
Inflammatory response Source: ProtInc
Cellular Location
Secreted
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Anti-IL17C antibodies

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Human IL17C ELISA Kit (V2LY-0626-LY2445)

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Target: IL17C
Sensitivity: 0.015 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant IL17C protein, hFc Tag (V2LY-0526-LY4773)

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Target: IL17C
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-197
Tag: hFc Tag
Datasheet SDS

Mouse Anti-IL17C Recombinant Antibody (CBYY-I1453) (CBMAB-I2623-YY)

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Target: IL17C
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I1453
Application*: F, WB
Datasheet SDS

Rat Anti-IL17C Recombinant Antibody (8B28) (CBMAB-I1750-YY)

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Target: IL17C
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 8B28
Application*: E, F
Datasheet SDS

Mouse Anti-IL17C Recombinant Antibody (7H4) (CBMAB-I1692-YY)

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Target: IL17C
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H4
Application*: F
Datasheet SDS

Mouse Anti-IL17C Recombinant Antibody (MM0375-9P31) (CBMAB-I0881-YY)

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Target: IL17C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0375-9P31
Application*: WB, F, MC
Datasheet SDS

Mouse Anti-IL17C Recombinant Antibody (177114) (CBMAB-I0419-YY)

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Target: IL17C
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 177114
Application*: WB, IH, IS, MC, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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