Human Recombinant IL17C protein, hFc Tag (V2LY-0526-LY4773)

Name: Human Recombinant IL17C protein, hFc Tag
SKU: V2LY-0526-LY4773
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant IL17C protein, hFc Tag consist of Amino Acid: 1-197 and predicts a molecular mass of 46.5 kDa.

Molecule Mass

46.5 kDa

Sequence

Amino Acid: 1-197

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 17C

Function

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

Biological Process

Cell-cell signaling Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
Inflammatory response Source: ProtInc

Cellular Location

Secreted

Swedik, S., Madola, A., & Levine, A. (2021). IL-17C in human mucosal immunity: More than just a middle child. Cytokine, 146, 155641.

Lee, Y., Kim, S. J., Choo, J., Heo, G., Yoo, J. W., Jung, Y., ... & Im, E. (2020). miR-23a-3p is a key regulator of IL-17C-induced tumor angiogenesis in colorectal cancer. Cells, 9(6), 1363.

Nies, J. F., & Panzer, U. (2020). IL-17C/IL-17RE: emergence of a unique axis in TH17 biology. Frontiers in Immunology, 11, 341.

Wang, F., Yin, J., Lin, Y., Zhang, F., Liu, X., Zhang, G., ... & Qian, Y. (2020). IL-17C has a pathogenic role in kidney ischemia/reperfusion injury. Kidney International, 97(6), 1219-1229.

Lauffer, F., Jargosch, M., Baghin, V., Krause, L., Kempf, W., Absmaier‐Kijak, M., ... & Eyerich, K. (2020). IL‐17C amplifies epithelial inflammation in human psoriasis and atopic eczema. Journal of the European Academy of Dermatology and Venereology, 34(4), 800-809.

Ritzmann, F., Jungnickel, C., Vella, G., Kamyschnikow, A., Herr, C., Li, D., ... & Beisswenger, C. (2019). IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer. Scientific Reports, 9(1), 10353.

Guttman-Yassky, E., & Krueger, J. G. (2018). IL-17C: a unique epithelial cytokine with potential for targeting across the spectrum of atopic dermatitis and psoriasis. Journal of Investigative Dermatology, 138(7), 1467-1469.

Yamaguchi, S., Nambu, A., Numata, T., Yoshizaki, T., Narushima, S., Shimura, E., ... & Nakae, S. (2018). The roles of IL-17C in T cell-dependent and-independent inflammatory diseases. Scientific Reports, 8(1), 15750.

Vandeghinste, N., Klattig, J., Jagerschmidt, C., Lavazais, S., Marsais, F., Haas, J. D., ... & Steidl, S. (2018). Neutralization of IL-17C reduces skin inflammation in mouse models of psoriasis and atopic dermatitis. Journal of Investigative Dermatology, 138(7), 1555-1563.

Krohn, S., Nies, J. F., Kapffer, S., Schmidt, T., Riedel, J. H., Kaffke, A., ... & Panzer, U. (2018). IL-17C/IL-17 receptor E signaling in CD4+ T cells promotes TH17 cell-driven glomerular inflammation. Journal of the American Society of Nephrology: JASN, 29(4), 1210.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human IL17C ELISA Kit (CAT#: V2LY-0626-LY2445)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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