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Rat Anti-KLK11 Recombinant Antibody (371604) (CBMAB-K1211-LY)

This product is antibody recognizes KLK11. The antibody 371604 immunoassay techniques such as: Neutralization.
See all KLK11 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
371604
Antibody Isotype
IgG2a
Application
Neutralization

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Kallikrein 11, Glu51-Asn282
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kallikrein Related Peptidase 11
Introduction
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
Entrez Gene ID
11012
UniProt ID
Q9UBX7
Alternative Names
Kallikrein Related Peptidase 11; Trypsin-Like Protease; Serine Protease 20; Hippostasin; PRSS20; TLSP; HK11;
Function
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Biological Process
Isoform 1
Secreted
Isoform 2
Golgi apparatus
PTM
About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.

Gong, Z., Dai, S., Jiang, X., Lee, M., Zhu, X., Wang, H., & Lin, Z. (2023). Variants in KLK11, affecting signal peptide cleavage of kallikrein-related peptidase 11, cause an autosomal-dominant cornification disorder. British Journal of Dermatology, 188(1), 100-111.

Ozturk, T., Kain, E. Z., Tuzuner, M. B., Diren, A., Batur, S., Yilmaz-Aydogan, H., ... & Isbir, T. (2021). Kallikrein 11 Down-regulation in Breast Carcinoma: Correlation With Prognostic Parameters. in vivo, 35(6), 3233-3243.

Liu, Y., Preis, S., Xiaocong, G., Gong, W., Kiechle, M., Dreyer, T., ... & Dorn, J. (2021). Kallikrein-related peptidases in triple negative breast cancer: prognostic value of quantitatively assessed KLK8, KLK10 and KLK11 mRNA expression.

He, X., Meng, F., Qin, L., Liu, Z., Zhu, X., Yu, Z., & Zheng, Y. (2019). KLK11 suppresses cellular proliferation via inhibition of Wnt/β-catenin signaling pathway in esophageal squamous cell carcinoma. American Journal of Cancer Research, 9(10), 2264.

Adamopoulos, P. G., Kontos, C. K., & Scorilas, A. (2018). Novel splice variants of the human kallikrein-related peptidases 11 (KLK11) and 12 (KLK12), unraveled by next-generation sequencing technology. Biological Chemistry, 399(9), 1065-1071.

Geng, X., Liu, Y., Dreyer, T., Bronger, H., Drecoll, E., Magdolen, V., & Dorn, J. (2018). Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients. American Journal of Cancer Research, 8(9), 1856.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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