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Rabbit Anti-LRMP Recombinant Antibody (EPR17852) (CBMAB-0337-WJ)

This product is a rabbit antibody that recognizes LRMP. The antibody EPR17852 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all LRMP antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EPR17852
Antibody Isotype
IgG
Application
WB, IHC-P, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LYMPHOID-RESTRICTED MEMBRANE PROTEIN
Introduction
LRMP (Lymphoid Restricted Membrane Protein) encodes the protein which is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. Diseases associated with LRMP include B-Cell Lymphomas and Respiratory System Benign Neoplasm. An important paralog of this gene is MRVI1.
Entrez Gene ID
4033
UniProt ID
Q12912
Alternative Names
LRMP; lymphoid-restricted membrane protein; JAW1; protein Jaw1
Function
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules.
Biological Process
Immune system processIEA:UniProtKB-KW
Nucleus organizationISS:UniProtKB
Single fertilizationIEA:UniProtKB-KW
Vesicle fusionManual Assertion Based On ExperimentTAS:ProtInc
Vesicle targetingManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Processed inositol 1,4,5-triphosphate receptor associated 2:
Cytoplasm
Endoplasmic reticulum membrane
Nucleus envelope
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle pole
Chromosome
Colocalized with ITPR3 on the endoplasmic reticulum membrane.
Topology
Cytoplasmic: 1-495
Helical: 496-516
Lumenal: 517-555
PTM
The removal of the C-terminal lumenal domain occurs by proteolytic processing.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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