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Mouse Anti-LTB Recombinant Antibody (CBYJT-1431) (CBMAB-T0455-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1431
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to human TNFSF3
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lymphotoxin Beta
Introduction
Lymphotoxin beta (LTB) is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha.
Entrez Gene ID
4050
UniProt ID
Q06643
Alternative Names
p33; TNFC; TNFSF3; TNLG1C
Function
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
Biological Process
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Gene expressionIEA:Ensembl
Immune responseIEA:InterPro
Lymph node developmentIEA:Ensembl
Positive regulation of interleukin-12 productionISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skin developmentIEA:Ensembl
Cellular Location
Membrane
Topology
Cytoplasmic: 1-18
Helical: 19-48
Extracellular: 49-244
More Infomation

Sun, L., Hu, L., Chen, P., Li, Y., Tu, J., & Chen, J. (2023). Long Non-Coding RNA AL928768. 3 Promotes Rheumatoid Arthritis Fibroblast-Like Synoviocytes Proliferation, Invasion and Inflammation, While Inhibits Apoptosis Via Activating Lymphotoxin Beta Mediated NF-κB Signaling Pathway. Inflammation, 1-14.

Harris, C. S., Miaskowski, C. A., Conley, Y. P., Hammer, M. J., Dhruva, A. A., Levine, J. D., ... & Kober, K. M. (2023). Gastrointestinal Symptom Cluster is Associated With Epigenetic Regulation of Lymphotoxin Beta in Oncology Patients Receiving Chemotherapy. Biological Research For Nursing, 25(1), 51-64.

Feng, X., Sun, R., Lee, M., Chen, X., Guo, S., Geng, H., ... & Pereira, J. P. (2023). Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling. Elife, 12, e83533.

Monaco, G., Khavaran, A., Gasull, A. D., Cahueau, J., Diebold, M., Chhatbar, C., ... & Sankowski, R. (2022). Transcriptome Analysis Identifies Accumulation of Natural Killer Cells with Enhanced Lymphotoxin-β Expression during Glioblastoma Progression. Cancers, 14(19), 4915.

Huang, R., Zeng, Z., Yan, P., Yin, H., Zhu, X., Hu, P., ... & Huang, Z. (2021). Targeting Lymphotoxin Beta and Paired Box 5: a potential therapeutic strategy for soft tissue sarcoma metastasis. Cancer Cell International, 21(1), 1-19.

Das, R., Coupar, J., Clavijo, P. E., Saleh, A., Cheng, T. F., Yang, X., ... & Chen, Z. (2019). Lymphotoxin‐β receptor‐NIK signaling induces alternative RELB/NF‐κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer. Molecular carcinogenesis, 58(3), 411-425.

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For research use only. Not intended for any clinical use.

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