Mouse Anti-LTB Recombinant Antibody (135105) (CBMAB-L2306-YJ)

Name: Mouse Anti-LTB Recombinant Antibody (135105)
SKU: CBMAB-L2306-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

135105

Application

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Lymphotoxin alpha/beta.ImmunogenType: Recombinant protein.

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Lymphotoxin Beta

Introduction

Lymphotoxin beta (LTB) is a type II membrane protein of the TNF family. LTB anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b has ability to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

Entrez Gene ID

4050

UniProt ID

Q06643

Alternative Names

p33; TNFC; TNFSF3; TNLG1C; lymphotoxin-beta; LT-beta; TNF superfamily member 3; TNF-C; lymphotoxin beta (TNF superfamily, member 3); tumor necrosis factor C; tumor necrosis factor ligand 1C; tumor necrosis factor ligand superfamily member 3

Function

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.

Biological Process

Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Gene expressionIEA:Ensembl
Immune responseIEA:InterPro
Lymph node developmentIEA:Ensembl
Positive regulation of interleukin-12 productionISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skin developmentIEA:Ensembl

Cellular Location

Membrane

Topology

Cytoplasmic: 1-18
Helical: 19-48
Extracellular: 49-244

Sun, L., Hu, L., Chen, P., Li, Y., Tu, J., & Chen, J. (2023). Long Non-Coding RNA AL928768. 3 Promotes Rheumatoid Arthritis Fibroblast-Like Synoviocytes Proliferation, Invasion and Inflammation, While Inhibits Apoptosis Via Activating Lymphotoxin Beta Mediated NF-κB Signaling Pathway. Inflammation, 1-14.

Harris, C. S., Miaskowski, C. A., Conley, Y. P., Hammer, M. J., Dhruva, A. A., Levine, J. D., ... & Kober, K. M. (2023). Gastrointestinal Symptom Cluster is Associated With Epigenetic Regulation of Lymphotoxin Beta in Oncology Patients Receiving Chemotherapy. Biological Research For Nursing, 25(1), 51-64.

Feng, X., Sun, R., Lee, M., Chen, X., Guo, S., Geng, H., ... & Pereira, J. P. (2023). Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling. Elife, 12, e83533.

Monaco, G., Khavaran, A., Gasull, A. D., Cahueau, J., Diebold, M., Chhatbar, C., ... & Sankowski, R. (2022). Transcriptome Analysis Identifies Accumulation of Natural Killer Cells with Enhanced Lymphotoxin-β Expression during Glioblastoma Progression. Cancers, 14(19), 4915.

Huang, R., Zeng, Z., Yan, P., Yin, H., Zhu, X., Hu, P., ... & Huang, Z. (2021). Targeting Lymphotoxin Beta and Paired Box 5: a potential therapeutic strategy for soft tissue sarcoma metastasis. Cancer Cell International, 21(1), 1-19.

Das, R., Coupar, J., Clavijo, P. E., Saleh, A., Cheng, T. F., Yang, X., ... & Chen, Z. (2019). Lymphotoxin‐β receptor‐NIK signaling induces alternative RELB/NF‐κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer. Molecular carcinogenesis, 58(3), 411-425.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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