Cynomolgus Recombinant LTB protein, His Tag (V2LY-0526-LY1600)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Cynomolgus
Tag
His Tag
Protein Construction
This product is Cynomolgus Recombinant LTB protein, His Tag consist of Amino Acid: 49-244 and predicts a molecular mass of 22.8 kDa.
Molecule Mass
22.8 kDa
Sequence
Amino Acid: 49-244
Species
Cynomolgus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>90% as determined by SDS-PAGE.
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
Lymphotoxin Beta
Function
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
Biological Process
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Gene expressionIEA:Ensembl
Immune responseIEA:InterPro
Lymph node developmentIEA:Ensembl
Positive regulation of interleukin-12 productionISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skin developmentIEA:Ensembl
Cellular Location
Membrane
Topology
Cytoplasmic: 1-18
Helical: 19-48
Extracellular: 49-244

Sun, L., Hu, L., Chen, P., Li, Y., Tu, J., & Chen, J. (2023). Long Non-Coding RNA AL928768. 3 Promotes Rheumatoid Arthritis Fibroblast-Like Synoviocytes Proliferation, Invasion and Inflammation, While Inhibits Apoptosis Via Activating Lymphotoxin Beta Mediated NF-κB Signaling Pathway. Inflammation, 1-14.

Harris, C. S., Miaskowski, C. A., Conley, Y. P., Hammer, M. J., Dhruva, A. A., Levine, J. D., ... & Kober, K. M. (2023). Gastrointestinal Symptom Cluster is Associated With Epigenetic Regulation of Lymphotoxin Beta in Oncology Patients Receiving Chemotherapy. Biological Research For Nursing, 25(1), 51-64.

Feng, X., Sun, R., Lee, M., Chen, X., Guo, S., Geng, H., ... & Pereira, J. P. (2023). Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling. Elife, 12, e83533.

Monaco, G., Khavaran, A., Gasull, A. D., Cahueau, J., Diebold, M., Chhatbar, C., ... & Sankowski, R. (2022). Transcriptome Analysis Identifies Accumulation of Natural Killer Cells with Enhanced Lymphotoxin-β Expression during Glioblastoma Progression. Cancers, 14(19), 4915.

Huang, R., Zeng, Z., Yan, P., Yin, H., Zhu, X., Hu, P., ... & Huang, Z. (2021). Targeting Lymphotoxin Beta and Paired Box 5: a potential therapeutic strategy for soft tissue sarcoma metastasis. Cancer Cell International, 21(1), 1-19.

Das, R., Coupar, J., Clavijo, P. E., Saleh, A., Cheng, T. F., Yang, X., ... & Chen, Z. (2019). Lymphotoxin‐β receptor‐NIK signaling induces alternative RELB/NF‐κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer. Molecular carcinogenesis, 58(3), 411-425.

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For research use only. Not intended for any clinical use.

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