LTB

Lymphotoxin beta (LTB) is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha.
Full Name
Lymphotoxin Beta
Function
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
Biological Process
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Gene expressionIEA:Ensembl
Immune responseIEA:InterPro
Lymph node developmentIEA:Ensembl
Positive regulation of interleukin-12 productionISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skin developmentIEA:Ensembl
Cellular Location
Membrane
Topology
Cytoplasmic: 1-18
Helical: 19-48
Extracellular: 49-244
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Anti-LTB antibodies

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Mouse Anti-LTB Recombinant Antibody (CBYJL-2139) (CBMAB-L2308-YJ)

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Target: LTB
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJL-2139
Application*: WB
Datasheet SDS

Mouse Anti-LTB Recombinant Antibody (135105) (CBMAB-L2306-YJ)

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Target: LTB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 135105
Application*: WB
Datasheet SDS

Mouse Anti-LTB Recombinant Antibody (CBYJT-1431) (CBMAB-T0455-YJ)

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Target: LTB
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-1431
Application*: WB
Datasheet SDS

Mouse Anti-LTB Recombinant Antibody (CBYCL-524) (CBMAB-L0425-YC)

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Target: LTB
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYCL-524
Application*: WB
Datasheet SDS

Mouse Anti-LTB Recombinant Antibody (MM0462-3J26) (CBMAB-L2309-YJ)

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Target: LTB
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0462-3J26
Application*: WB, P
Datasheet SDS

Mouse Anti-LTB Recombinant Antibody (399CT9.3.4) (CBMAB-L2307-YJ)

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Target: LTB
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 399CT9.3.4
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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