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LTB

Lymphotoxin beta (LTB) is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha.

Full Name

Lymphotoxin Beta

Function

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.

Biological Process

Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Gene expressionIEA:Ensembl
Immune responseIEA:InterPro
Lymph node developmentIEA:Ensembl
Positive regulation of interleukin-12 productionISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skin developmentIEA:Ensembl

Cellular Location

Membrane

Topology

Cytoplasmic: 1-18
Helical: 19-48
Extracellular: 49-244

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Anti-LTB antibodies

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Mouse Anti-LTB Recombinant Antibody (CBYJL-2139) (CBMAB-L2308-YJ)

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Target: LTB

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYJL-2139

Application*: WB

Mouse Anti-LTB Recombinant Antibody (135105) (CBMAB-L2306-YJ)

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Target: LTB

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 135105

Application*: WB

Mouse Anti-LTB Recombinant Antibody (CBYJT-1431) (CBMAB-T0455-YJ)

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Target: LTB

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYJT-1431

Application*: WB

Mouse Anti-LTB Recombinant Antibody (CBYCL-524) (CBMAB-L0425-YC)

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Target: LTB

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: CBYCL-524

Application*: WB

Mouse Anti-LTB Recombinant Antibody (MM0462-3J26) (CBMAB-L2309-YJ)

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Target: LTB

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: MM0462-3J26

Application*: WB, P

Mouse Anti-LTB Recombinant Antibody (399CT9.3.4) (CBMAB-L2307-YJ)

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Target: LTB

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: 399CT9.3.4

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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