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Mouse Anti-mys Antibody (CF.6G11) (CBMAB-1443CQ)

This product is a mouse antibody that recognizes mys. The antibody CF.6G11 can be used for immunoassay techniques such as: FC, IF, IHC, IP, WB.
See all mys antibodies

Summary

Host Animal
Mouse
Specificity
Common fruit fly
Clone
CF.6G11
Antibody Isotype
IgG2b, κ
Application
FC, IF, IHC, IP, WB

Basic Information

Immunogen
Sonicated imaginal discs
Specificity
Common fruit fly
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
myospheroid
Introduction
Myospheroid (Mys) is a β subunit of the integrin dimer. Integrin transmembrane receptors function as a link for the extracellular matrix and the intracellular actin cytoskeleton. Mys acts as adhesion/signaling protein regulating cellular adhesion, migration and survival.
Entrez Gene ID
44885
UniProt ID
P11584
Alternative Names
beta integrin; beta-int; beta-Int; beta-integrin; beta-PS; beta1; betaInt; betamys; betaPS; BetaPS; betaPS Int; betaPS integrin; BetaPS-Int; betaPS-integrin; betaPS1
Function
Integrin alpha-PS1/beta-PS is a receptor for laminin (PubMed:7972082).

Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m (PubMed:7924982, PubMed:7972082, PubMed:9660786).

Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle (PubMed:15469969).

Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium (PubMed:15469969).

The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not (PubMed:15469969).

Required for rhea/talin correct cellular localization in the midgut (PubMed:15469969).

Required for many embryonic (dorsal closure and somatic muscle attachments) and postembryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development) (PubMed:8119134, PubMed:7924982, PubMed:7972082, PubMed:10821184).

Involved in the function and/or development of the olfactory system (PubMed:10821184).

In the testes, essential for shv-dependent maintenance of somatic hub cells and their localization to the apical tip (PubMed:27191715).

Plays a role in timely border cell migration during oogenesis (PubMed:19035354).
Biological Process
Actin filament organization Source: FlyBase
Axon guidance Source: FlyBase
Border follicle cell migration Source: FlyBase
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
Calcium-dependent cell-matrix adhesion Source: FlyBase
Cell adhesion mediated by integrin Source: FlyBase
Cell-matrix adhesion Source: GO_Central
Cell migration Source: GO_Central
Cell-substrate adhesion Source: FlyBase
Central nervous system development Source: FlyBase
Central nervous system morphogenesis Source: FlyBase
Determination of adult lifespan Source: FlyBase
Dorsal closure Source: FlyBase
Dorsal trunk growth, open tracheal system Source: FlyBase
Flight behavior Source: UniProtKB-KW
Germ-band extension Source: FlyBase
Germ-line stem cell population maintenance Source: FlyBase
Hemocyte migration Source: FlyBase
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
Imaginal disc-derived male genitalia morphogenesis Source: FlyBase
Imaginal disc-derived wing morphogenesis Source: FlyBase
Integrin-mediated signaling pathway Source: FlyBase
Larval heart development Source: FlyBase
Maintenance of epithelial integrity, open tracheal system Source: FlyBase
Midgut development Source: FlyBase
Muscle attachment Source: FlyBase
Muscle organ development Source: FlyBase
Negative regulation of cell migration Source: UniProtKB
Pericardium morphogenesis Source: FlyBase
Positive regulation of synapse maturation Source: FlyBase
Regulation of cell shape Source: FlyBase
Regulation of stress fiber assembly Source: FlyBase
Salivary gland development Source: FlyBase
Sarcomere organization Source: FlyBase
Sensory perception of smell Source: FlyBase
Substrate adhesion-dependent cell spreading Source: FlyBase
Substrate-dependent cell migration, cell extension Source: FlyBase
Ventral cord development Source: FlyBase
Visual perception Source: UniProtKB-KW
Cellular Location
Plasma membrane
Apical cell membrane
Lateral cell membrane
Basal cell membrane
Note: In ovary, localizes to the apical, lateral and basal membranes of follicle cells through oogenesis stage 10A. Apical membrane expression peaks at oogenesis stages 9 and 10A in columnar follicle cells overlying the oocyte but decreases in the most posterior follicle cells. Thereafter, it is down-regulated. Localization to lateral and basal membranes persists during dorsal appendage morphogenesis.
Topology
Extracellular: 24-776
Helical: 777-799
Cytoplasmic: 800-846
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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