mys

Myospheroid (Mys) is a β subunit of the integrin dimer. Integrin transmembrane receptors function as a link for the extracellular matrix and the intracellular actin cytoskeleton. Mys acts as adhesion/signaling protein regulating cellular adhesion, migration and survival.

Full Name

myospheroid

Function

Integrin alpha-PS1/beta-PS is a receptor for laminin (PubMed:7972082).

Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m (PubMed:7924982, PubMed:7972082, PubMed:9660786).

Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle (PubMed:15469969).

Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium (PubMed:15469969).

The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not (PubMed:15469969).

Required for rhea/talin correct cellular localization in the midgut (PubMed:15469969).

Required for many embryonic (dorsal closure and somatic muscle attachments) and postembryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development) (PubMed:8119134, PubMed:7924982, PubMed:7972082, PubMed:10821184).

Involved in the function and/or development of the olfactory system (PubMed:10821184).

In the testes, essential for shv-dependent maintenance of somatic hub cells and their localization to the apical tip (PubMed:27191715).

Plays a role in timely border cell migration during oogenesis (PubMed:19035354).

Biological Process

Actin filament organization Source: FlyBase
Axon guidance Source: FlyBase
Border follicle cell migration Source: FlyBase
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
Calcium-dependent cell-matrix adhesion Source: FlyBase
Cell adhesion mediated by integrin Source: FlyBase
Cell-matrix adhesion Source: GO_Central
Cell migration Source: GO_Central
Cell-substrate adhesion Source: FlyBase
Central nervous system development Source: FlyBase
Central nervous system morphogenesis Source: FlyBase
Determination of adult lifespan Source: FlyBase
Dorsal closure Source: FlyBase
Dorsal trunk growth, open tracheal system Source: FlyBase
Flight behavior Source: UniProtKB-KW
Germ-band extension Source: FlyBase
Germ-line stem cell population maintenance Source: FlyBase
Hemocyte migration Source: FlyBase
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
Imaginal disc-derived male genitalia morphogenesis Source: FlyBase
Imaginal disc-derived wing morphogenesis Source: FlyBase
Integrin-mediated signaling pathway Source: FlyBase
Larval heart development Source: FlyBase
Maintenance of epithelial integrity, open tracheal system Source: FlyBase
Midgut development Source: FlyBase
Muscle attachment Source: FlyBase
Muscle organ development Source: FlyBase
Negative regulation of cell migration Source: UniProtKB
Pericardium morphogenesis Source: FlyBase
Positive regulation of synapse maturation Source: FlyBase
Regulation of cell shape Source: FlyBase
Regulation of stress fiber assembly Source: FlyBase
Salivary gland development Source: FlyBase
Sarcomere organization Source: FlyBase
Sensory perception of smell Source: FlyBase
Substrate adhesion-dependent cell spreading Source: FlyBase
Substrate-dependent cell migration, cell extension Source: FlyBase
Ventral cord development Source: FlyBase
Visual perception Source: UniProtKB-KW

Cellular Location

Plasma membrane
Apical cell membrane
Lateral cell membrane
Basal cell membrane
Note: In ovary, localizes to the apical, lateral and basal membranes of follicle cells through oogenesis stage 10A. Apical membrane expression peaks at oogenesis stages 9 and 10A in columnar follicle cells overlying the oocyte but decreases in the most posterior follicle cells. Thereafter, it is down-regulated. Localization to lateral and basal membranes persists during dorsal appendage morphogenesis.

Topology

Extracellular: 24-776
Helical: 777-799
Cytoplasmic: 800-846