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Rabbit Anti-NFASC Monoclonal Antibody (EPR19004) (CBMAB-1416-YC)

Provided herein is a rabbit monoclonal antibody against Mouse NFASC. The antibody, clone EPR19004, can be used for immunoassay techniques, such as IHC-P and WB.
See all NFASC antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat
Clone
EPR19004
Antibody Isotype
IgG
Application
IHC-P, WB

Basic Information

Immunogen
Recombinant fragment within Mouse Neurofascin aa 600-850.
Specificity
Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
neurofascin
Introduction
NFASC is an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development.
Entrez Gene ID
Mouse269116
Rat116690
UniProt ID
MouseQ810U3
RatP97685
Alternative Names
NF; AA387016; mKIAA0756; D430023G06Rik
Function
Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.
Biological Process
Axon guidance Source: GO_Central
Brain development Source: GO_Central
Cell-cell adhesion Source: GO_Central
Myelination Source: BHF-UCL
Peripheral nervous system development Source: BHF-UCL
Protein localization to plasma membrane Source: Ensembl
Synapse organization Source: InterPro
Transmission of nerve impulse Source: InterPro
Cellular Location
Plasma membrane
Cell membrane
Isoform 8:
Other locations
paranodal septate junction
Involvement in disease
Neurodevelopmental disorder with central and peripheral motor dysfunction (NEDCPMD):
An autosomal recessive neurodevelopmental disorder with early onset and a highly variable phenotype. Disease features include hypotonia apparent from birth, poor feeding, global developmental delay with absence of reaction to touch and no eye contact, infantile-onset progressive ataxia and demyelinating peripheral neuropathy.
Topology
Extracellular: 25-1217
Helical: 1218-1238
Cytoplasmic: 1239-1347
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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