Sign in or Register   Sign in or Register
  |  

Rabbit Anti-NFASC Recombinant Antibody (D6G6O) (CBMAB-CP1681-LY)

The product is antibody recognizes Neurofascin 186. The antibody D6G6O immunoassay techniques such as: WB,IP,IF.
See all NFASC antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D6G6O
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr1108 of human neurofascin 186 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
neurofascin
Entrez Gene ID
Human23114
Mouse269116
Rat116690
UniProt ID
HumanO94856
MouseQ810U3
RatP97685
Function
Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.
Biological Process
Axon guidance Source: GO_Central
Brain development Source: GO_Central
Cell-cell adhesion Source: GO_Central
Myelination Source: BHF-UCL
Peripheral nervous system development Source: BHF-UCL
Protein localization to plasma membrane Source: Ensembl
Synapse organization Source: InterPro
Transmission of nerve impulse Source: InterPro
Cellular Location
Plasma membrane
Cell membrane
Isoform 8:
Other locations
paranodal septate junction
Involvement in disease
Neurodevelopmental disorder with central and peripheral motor dysfunction (NEDCPMD):
An autosomal recessive neurodevelopmental disorder with early onset and a highly variable phenotype. Disease features include hypotonia apparent from birth, poor feeding, global developmental delay with absence of reaction to touch and no eye contact, infantile-onset progressive ataxia and demyelinating peripheral neuropathy.
Topology
Extracellular: 25-1217
Helical: 1218-1238
Cytoplasmic: 1239-1347
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-NFASC Recombinant Antibody (D6G6O)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare