Human NFASC ELISA Kit (V2LY-0626-LY4947)

Name: Human NFASC ELISA Kit
SKU: V2LY-0626-LY4947
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.026 ng/mL

Detection Range

0.05-20 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

150.0 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

neurofascin

Function

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.

Biological Process

Axon guidance Source: GO_Central
Brain development Source: GO_Central
Cell-cell adhesion Source: GO_Central
Myelination Source: BHF-UCL
Peripheral nervous system development Source: BHF-UCL
Protein localization to plasma membrane Source: Ensembl
Synapse organization Source: InterPro
Transmission of nerve impulse Source: InterPro

Cellular Location

Plasma membrane
Cell membrane
Isoform 8:
Other locations
paranodal septate junction

Involvement in disease

Neurodevelopmental disorder with central and peripheral motor dysfunction (NEDCPMD):
An autosomal recessive neurodevelopmental disorder with early onset and a highly variable phenotype. Disease features include hypotonia apparent from birth, poor feeding, global developmental delay with absence of reaction to touch and no eye contact, infantile-onset progressive ataxia and demyelinating peripheral neuropathy.

Topology

Extracellular: 25-1217
Helical: 1218-1238
Cytoplasmic: 1239-1347

Chen, P., Yao, M., Fang, T., Ye, C., Du, Y., Jin, Y., & Wu, R. (2022). Identification of NFASC and CHL1 as two novel hub genes in endometriosis using integrated bioinformatic analysis and experimental verification. Pharmacogenomics and Personalized Medicine, 377-392.

Harper, J. L., Wilson, T. E., & Mitchell, R. M. (2020). Case report of two children with auditory neuropathy spectrum disorder related to a neurofascin (NFASC) gene variant. International Journal of Pediatric Otorhinolaryngology, 131, 109863.

Kvarnung, M., Shahsavani, M., Taylan, F., Moslem, M., Breeuwsma, N., Laan, L., ... & Falk, A. (2019). Ataxia in patients with bi-allelic NFASC mutations and absence of full-length NF186. Frontiers in genetics, 10, 896.

Wu, J., Huang, W. J., Xi, H. L., Liu, L. Y., Wang, S. T., Fan, W. Z., & Peng, B. G. (2019). Tumor-suppressive miR-3650 inhibits tumor metastasis by directly targeting NFASC in hepatocellular carcinoma. Aging (Albany NY), 11(11), 3432.

Monfrini, E., Straniero, L., Bonato, S., Compagnoni, G. M., Bordoni, A., Dilena, R., ... & Di Fonzo, A. (2019). Neurofascin (NFASC) gene mutation causes autosomal recessive ataxia with demyelinating neuropathy. Parkinsonism & Related Disorders, 63, 66-72.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant NFASC protein, hFc Tag (CAT#: V2LY-0526-LY5762)

Human Recombinant NFASC protein, Biotin Conjugated, hFc Tag (CAT#: V2LY-0526-LY5763)

Human Recombinant NFASC protein, His Tag (CAT#: V2LY-0526-LY5764)

Related Products

Rabbit Anti-NFASC Recombinant Antibody (D6G6O) (CAT#: CBMAB-CP1681-LY)

Mouse Anti-NFASC Recombinant Antibody (CBWJN-1355) (CAT#: CBMAB-N2143-WJ)

Mouse Anti-NFASC Recombinant Antibody (CBWJN-1354) (CAT#: CBMAB-N2142-WJ)

Human Recombinant NFASC protein, hFc Tag (CAT#: V2LY-0526-LY5762)

Human Recombinant NFASC protein, Biotin Conjugated, hFc Tag (CAT#: V2LY-0526-LY5763)

Human Recombinant NFASC protein, His Tag (CAT#: V2LY-0526-LY5764)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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