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Mouse Anti-NTS Recombinant Antibody (1G8) (CBMAB-N3815-WJ)

This product is a Mouse antibody that recognizes NTS. The antibody 1G8 can be used for immunoassay techniques such as: ELISA.
See all NTS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G8
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
neurotensin
Introduction
This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]
Entrez Gene ID
4922
UniProt ID
P30990
Alternative Names
Neurotensin; Pro-Neurotensin/Neuromedin; Neurotensin/Neuromedin N; Neuromedin N; NMN-125; NT/N; NTS1; NT; NN;
Function
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Killing of cells of another organismIDA:UniProtKB
Negative regulation of gene expressionManual Assertion Based On ExperimentIDA:ARUK-UCL
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:ARUK-UCL
Signal transduction1 PublicationNAS:ProtInc
Cellular Location
Secreted
Cytoplasmic vesicle, secretory vesicle
Packaged within secretory vesicles.

Hung, Y. H., Wang, H. C., Hsu, S. H., Wang, L. Y., Tsai, Y. L., Su, Y. Y., ... & Chen, L. T. (2024). Neuron-derived neurotensin promotes pancreatic cancer invasiveness and gemcitabine resistance via the NTSR1/Akt pathway. American Journal of Cancer Research, 14(2), 448.

Arbogast, P., Gauchotte, G., Mougel, R., Morel, O., Ziyyat, A., & Agopiantz, M. (2023). Neurotensin and its involvement in reproductive functions: An exhaustive review of the literature. International Journal of Molecular Sciences, 24(5), 4594.

Gereau, G. B., Garrison, S. K. D., & McElligott, Z. A. (2023). Neurotensin and energy balance. Journal of Neurochemistry, 166(2), 189-200.

Campbell, G. E., Bender, H. R., Parker, G. A., Curry Jr, T. E., & Duffy, D. M. (2021). Neurotensin: a novel mediator of ovulation?. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 35(4), e21481.

Ramirez-Virella, J., & Leinninger, G. M. (2021). The role of central neurotensin in regulating feeding and body weight. Endocrinology, 162(5), bqab038.

Li, J., Li, E., Czepielewski, R. S., Chi, J., Guo, X., Han, Y. H., ... & Rosen, E. D. (2021). Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells. Cell metabolism, 33(7), 1449-1465.

Torruella-Suárez, M. L., & McElligott, Z. A. (2020). Neurotensin in reward processes. Neuropharmacology, 167, 108005.

Christou, N., Blondy, S., David, V., Verdier, M., Lalloué, F., Jauberteau, M. O., ... & Perraud, A. (2020). Neurotensin pathway in digestive cancers and clinical applications: an overview. Cell Death & Disease, 11(12), 1027.

Tabarean, I. V. (2020). Neurotensin induces hypothermia by activating both neuronal neurotensin receptor 1 and astrocytic neurotensin receptor 2 in the median preoptic nucleus. Neuropharmacology, 171, 108069.

Schroeder, L. E., Furdock, R., Quiles, C. R., Kurt, G., Perez-Bonilla, P., Garcia, A., ... & Leinninger, G. M. (2019). Mapping the populations of neurotensin neurons in the male mouse brain. Neuropeptides, 76, 101930.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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