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Mouse Anti-PCMT1 Recombinant Antibody (4G9) (CBMAB-0607CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
4G9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PCMT1 (aa 1-228)
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein-L-isoaspartate (D-aspartate) O-methyltransferase
Introduction
This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.
Entrez Gene ID
Human5110
Rat25604
UniProt ID
HumanP22061
RatP22062
Alternative Names
PIMT
Function
Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980).
Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
Biological Process
Protein methylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein repairManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm, cytosol
More Infomation

Zhang, K., Li, J. Y., & Li, K. (2024). Silencing PCMT1 enhances the sensitivity of breast cancer cells to paclitaxel through the PI3K/Akt/STMN1 pathway. Chemical Biology & Drug Design, 103(6), e14559.

Zhong, J., Yuan, C., Liu, L., Du, Y., Hui, Y., Chen, Z., ... & Liu, X. (2023). PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway. Aging (Albany NY), 15(20), 11654.

Zhang, Z., Li, F., Li, Y., Li, Z., & Jia, G. (2023). In vitro anti-malignant property of PCMT1 silencing and identification of the SNHG16/miR-195/PCMT1 regulatory axis in breast cancer cells. Clinical Breast Cancer, 23(3), 302-316.

Liu, J., Liu, B., Li, Y., Mi, Z., Tan, H., & Rong, P. (2023). PCMT1 is a potential target related to tumor progression and immune infiltration in liver cancer. European Journal of Medical Research, 28(1), 289.

Guo, J., Du, X., & Li, C. (2022). PCMT1 is a potential prognostic biomarker and is correlated with immune infiltrates in breast cancer. BioMed research international, 2022(1), 4434887.

Zhang, J., Li, Y., Liu, H., Zhang, J., Wang, J., Xia, J., ... & Feng, W. (2022). Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis. Journal of Experimental & Clinical Cancer Research, 41(1), 24.

Lin, Y. W., Wu, F. C., Zhuang, Y. X., Chu, L. Y., Ding, T. Y., Qu, Q. Q., ... & Hong, C. Q. (2022). PCMT1 has Potential Prognostic Value and Promotes Cell Growth and Motility in Breast Cancer.

Yuan, C., Liu, L., Du, Y., Chen, Z., Wang, L., Liu, Z., ... & Liu, X. (2022). PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway.

Dong, L. M., Zhang, X. L., Mao, M. H., Li, Y. P., Zhang, X. Y., Xue, D. W., & Liu, Y. L. (2021). LINC00511/miRNA-143-3p modulates apoptosis and malignant phenotype of bladder carcinoma cells via PCMT1. Frontiers in Cell and Developmental Biology, 9, 650999.

Ozay, E. I., Shanthalingam, S., Torres, J. A., Osborne, B. A., Tew, G. N., & Minter, L. M. (2020). Protein kinase C theta modulates PCMT1 through hnRNPL to regulate FOXP3 stability in regulatory T cells. Molecular Therapy, 28(10), 2220-2236.

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For research use only. Not intended for any clinical use.

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