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Mouse Anti-PCMT1 Recombinant Antibody (4G9) (CBMAB-0607CQ)

This product is a mouse antibody that recognizes PCMT1. The antibody 4G9 can be used for immunoassay techniques such as: WB, ELISA.
See all PCMT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
4G9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PCMT1 (aa 1-228)
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein-L-isoaspartate (D-aspartate) O-methyltransferase
Introduction
This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.
Entrez Gene ID
Human5110
Rat25604
UniProt ID
HumanP22061
RatP22062
Alternative Names
PIMT
Function
Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980).
Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
Biological Process
Protein methylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein repairManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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