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Mouse Anti-PCMT1 Recombinant Antibody (2A9) (CBMAB-P1063-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase. The antibody can be used for immunoassay techniques, such as WB, IHC.
See all PCMT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A9
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 60-285 of human PCMT1(NP_005380) produced in E. coli
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein-L-isoaspartate (D-aspartate) O-methyltransferase
Introduction
PCMT1 is a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure.
Entrez Gene ID
5110
UniProt ID
P22061
Alternative Names
Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase; Protein L-Isoaspartyl/D-Aspartyl Methyltransferase; L-Isoaspartyl Protein Carboxyl Methyltransferase; Protein-Beta-Aspartate Methyltransferase; EC 2.1.1.77; PIMT; Protein-L-Isoaspartate(D-Aspartate) O-Methyltransferase; EC 2.1.1;
Function
Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980).
Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
Biological Process
Protein methylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein repairManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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