Human Recombinant PCMT1 protein, GST Tag (V2LY-0526-LY5988)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant PCMT1 protein, GST Tag consist of Amino Acid: 2-end and predicts a molecular mass of 51 kDa.
Molecule Mass
51 kDa
Sequence
Amino Acid: 2-end
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
PBS
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
protein-L-isoaspartate (D-aspartate) O-methyltransferase
Function
Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980).
Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
Biological Process
Protein methylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein repairManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm, cytosol

Zhang, K., Li, J. Y., & Li, K. (2024). Silencing PCMT1 enhances the sensitivity of breast cancer cells to paclitaxel through the PI3K/Akt/STMN1 pathway. Chemical Biology & Drug Design, 103(6), e14559.

Zhong, J., Yuan, C., Liu, L., Du, Y., Hui, Y., Chen, Z., ... & Liu, X. (2023). PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway. Aging (Albany NY), 15(20), 11654.

Zhang, Z., Li, F., Li, Y., Li, Z., & Jia, G. (2023). In vitro anti-malignant property of PCMT1 silencing and identification of the SNHG16/miR-195/PCMT1 regulatory axis in breast cancer cells. Clinical Breast Cancer, 23(3), 302-316.

Liu, J., Liu, B., Li, Y., Mi, Z., Tan, H., & Rong, P. (2023). PCMT1 is a potential target related to tumor progression and immune infiltration in liver cancer. European Journal of Medical Research, 28(1), 289.

Guo, J., Du, X., & Li, C. (2022). PCMT1 is a potential prognostic biomarker and is correlated with immune infiltrates in breast cancer. BioMed research international, 2022(1), 4434887.

Zhang, J., Li, Y., Liu, H., Zhang, J., Wang, J., Xia, J., ... & Feng, W. (2022). Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis. Journal of Experimental & Clinical Cancer Research, 41(1), 24.

Lin, Y. W., Wu, F. C., Zhuang, Y. X., Chu, L. Y., Ding, T. Y., Qu, Q. Q., ... & Hong, C. Q. (2022). PCMT1 has Potential Prognostic Value and Promotes Cell Growth and Motility in Breast Cancer.

Yuan, C., Liu, L., Du, Y., Chen, Z., Wang, L., Liu, Z., ... & Liu, X. (2022). PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway.

Dong, L. M., Zhang, X. L., Mao, M. H., Li, Y. P., Zhang, X. Y., Xue, D. W., & Liu, Y. L. (2021). LINC00511/miRNA-143-3p modulates apoptosis and malignant phenotype of bladder carcinoma cells via PCMT1. Frontiers in Cell and Developmental Biology, 9, 650999.

Ozay, E. I., Shanthalingam, S., Torres, J. A., Osborne, B. A., Tew, G. N., & Minter, L. M. (2020). Protein kinase C theta modulates PCMT1 through hnRNPL to regulate FOXP3 stability in regulatory T cells. Molecular Therapy, 28(10), 2220-2236.

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For research use only. Not intended for any clinical use.

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