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PCMT1

Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM

Full Name

protein-L-isoaspartate (D-aspartate) O-methyltransferase

Function

Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980).
Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).

Biological Process

Protein methylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein repairManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Cytoplasm, cytosol

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Anti-PCMT1 antibodies

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Human Recombinant PCMT1 protein, GST Tag (V2LY-0526-LY5988)

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Target: PCMT1

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 2-end

Tag: GST Tag

Human Recombinant PCMT1 protein, GST Tag

Mouse Anti-PCMT1 Recombinant Antibody (CBYC-P220) (CBMAB-P1065-YC)

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Target: PCMT1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYC-P220

Application*: E, WB

Mouse Anti-PCMT1 Recombinant Antibody (CBYC-P220)

Mouse Anti-PCMT1 Recombinant Antibody (2A9) (CBMAB-P1063-YC)

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Target: PCMT1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2A9

Application*: WB, IH

Mouse Anti-PCMT1 Recombinant Antibody (2A9)

Mouse Anti-PCMT1 Recombinant Antibody (1D6) (CBMAB-0608CQ)

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Target: PCMT1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: 1D6

Application*: WB, E

Mouse Anti-PCMT1 Recombinant Antibody (1D6)

Mouse Anti-PCMT1 Recombinant Antibody (4G9) (CBMAB-0607CQ)

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Target: PCMT1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Rat

Clone: 4G9

Application*: WB, E

Mouse Anti-PCMT1 Recombinant Antibody (4G9)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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