Sign in or Register   Sign in or Register
  |  

Mouse Anti-RAMP1 Recombinant Antibody (CBCNR-171) (CBMAB-R1257-CN)

This product is a Mouse antibody that recognizes RAMP1. The antibody CBCNR-171 can be used for immunoassay techniques such as: WB, ELISA.
See all RAMP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-171
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
RAMP1 (NP_005846, aa. 27-117) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1× PBS, pH 7.2

Target

Full Name
receptor (G protein-coupled) activity modifying protein 1
Introduction
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Entrez Gene ID
10267
UniProt ID
O60894
Alternative Names
Receptor Activity Modifying Protein 1; Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 1; CRLR Activity-Modifying Protein 1;
Function
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
Biological Process
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process amylin receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process calcitonin gene-related peptide receptor signaling pathwayManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportIEA:InterPro
Biological Process positive regulation of protein glycosylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process receptor internalizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of G protein-coupled receptor signaling pathwayIEA:InterPro
Cellular Location
Membrane
Topology
Extracellular: 27-117
Helical: 118-138
Cytoplasmic: 139-148
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-RAMP1 Recombinant Antibody (CBCNR-171)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare