Rabbit Anti-RELN Recombinant Antibody (EPR3330(2)) (CBMAB-1760-CN)

Rabbit

Human, Rat

EPR3330(2)

IgG

WB

Synthetic peptide

Human, Rat

IgG

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

50% Glycerol, 0.05% BSA

0.01% Sodium azide

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Reelin

This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration.

RL; ETL7; LIS2; PRO1598

Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity).

Biological Process associative learningIEA:Ensembl
Biological Process axon guidanceISS:UniProtKB
Biological Process brain developmentISS:UniProtKB
Biological Process cell adhesionIEA:UniProtKB-KW
Biological Process cell morphogenesis involved in differentiationISS:UniProtKB
Biological Process central nervous system developmentISS:UniProtKB
Biological Process cerebral cortex tangential migrationISS:UniProtKB
Biological Process dendrite developmentIEA:Ensembl
Biological Process glial cell differentiationISS:UniProtKB
Biological Process hippocampus developmentISS:BHF-UCL
Biological Process interneuron migrationIEA:Ensembl
Biological Process lateral motor column neuron migrationIEA:Ensembl
Biological Process layer formation in cerebral cortexIEA:Ensembl
Biological Process locomotory behaviorIEA:Ensembl
Biological Process long-term memoryIEA:Ensembl
Biological Process long-term synaptic potentiationIEA:Ensembl
Biological Process modulation of chemical synaptic transmissionISS:BHF-UCL
Biological Process neuron migrationISS:UniProtKB
Biological Process NMDA glutamate receptor clusteringIEA:Ensembl
Biological Process peptidyl-tyrosine phosphorylationISS:UniProtKB
Biological Process positive regulation of AMPA receptor activityISS:BHF-UCL
Biological Process positive regulation of CREB transcription factor activityISS:BHF-UCL
Biological Process positive regulation of dendritic spine morphogenesisISS:BHF-UCL
Biological Process positive regulation of excitatory postsynaptic potentialISS:BHF-UCL
Biological Process positive regulation of lateral motor column neuron migrationIEA:Ensembl
Biological Process positive regulation of long-term synaptic potentiationISS:BHF-UCL
Biological Process positive regulation of neuron projection developmentISS:BHF-UCL
Biological Process positive regulation of peptidyl-tyrosine phosphorylationBy SimilarityISS:BHF-UCL
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingIEA:Ensembl
Biological Process positive regulation of protein kinase activityISS:UniProtKB
Biological Process positive regulation of protein tyrosine kinase activityISS:BHF-UCL
Biological Process positive regulation of small GTPase mediated signal transductionISS:UniProtKB
Biological Process positive regulation of synapse maturationISS:BHF-UCL
Biological Process positive regulation of synaptic transmission, glutamatergicISS:BHF-UCL
Biological Process positive regulation of TOR signalingIEA:Ensembl
Biological Process postsynaptic density protein 95 clusteringIEA:Ensembl
Biological Process protein localization to synapseIEA:Ensembl
Biological Process proteolysisIEA:UniProtKB-KW
Biological Process receptor localization to synapseIEA:Ensembl
Biological Process reelin-mediated signaling pathwayBy SimilarityISS:BHF-UCL
Biological Process regulation of behaviorISS:BHF-UCL
Biological Process regulation of neuron differentiation1 PublicationIC:ComplexPortal
Biological Process regulation of neuron migration1 PublicationIC:ComplexPortal
Biological Process regulation of NMDA receptor activityISS:BHF-UCL
Biological Process regulation of synaptic activity1 PublicationIC:ComplexPortal
Biological Process response to painISS:UniProtKB
Biological Process spinal cord patterningISS:UniProtKB
Biological Process ventral spinal cord developmentIEA:Ensembl

Secreted, extracellular space, extracellular matrix

Lissencephaly 2 (LIS2):
A classic type lissencephaly associated with ataxia, intellectual disability, seizures and abnormalities of the cerebellum, hippocampus and brainstem.
Epilepsy, familial temporal lobe, 7 (ETL7):
A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.