Sign in or Register   Sign in or Register
  |  

Mouse Anti-RRM2 Recombinant Antibody (1E1) (CBMAB-R3689-CN)

This product is a Mouse antibody that recognizes RRM2. The antibody 1E1 can be used for immunoassay techniques such as: ELISA, IF, IP, WB.
See all RRM2 antibodies
Published Data
Fig.1 Representative images of RRM2 staining in human pancreatic cancer tissues expressing high levels of VASH2 are shown.
...View More
Fig.2 JUN and RRM2 immunobloting in PANC-1-EGFP and PANC-1-VASH2 transfected with siRNA against JUN.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E1
Antibody Isotype
IgG1
Application
ELISA, IF, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ribonucleotide Reductase Regulatory Subunit M2
Introduction
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
Entrez Gene ID
6241
UniProt ID
P31350
Alternative Names
Ribonucleotide Reductase Regulatory Subunit M2; Ribonucleotide Reductase M2 Polypeptide; Ribonucleotide Reductase Small Subunit; Ribonucleotide Reductase Small Chain; EC 1.17.4.1; RR2; Ribonucleoside-Diphosphate Reductase Subunit M2; RR2M; R2;
Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Biological Process
Biological Process 2'-deoxyribonucleotide biosynthetic processManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process blastocyst developmentIEA:Ensembl
Biological Process deoxyribonucleotide biosynthetic processISS:UniProtKB
Biological Process DNA replicationIEA:UniProtKB-UniPathway
Biological Process positive regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process protein heterotetramerizationIEA:Ensembl
Biological Process ribonucleoside diphosphate metabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Cytoplasm
Nucleus
Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells.
PTM
Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. Phosphorylated on Thr-33 by CDK1 and CDK2; predominantly in G2 and M phase (PubMed:22632967).
Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-RRM2 Recombinant Antibody (1E1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare