Sign in or Register   Sign in or Register
  |  

Mouse Anti-RRM2 Antibody (11BA12) (CBMAB-1540CQ)

This product is a mouse antibody that recognizes RRM2. The antibody 11BA12 can be used for immunoassay techniques such as: ELISA.
See all RRM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
11BA12
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Synthetic Peptide (DIQHWESLKPEER)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ribonucleotide Reductase Regulatory Subunit M2
Introduction
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Diseases associated with RRM2 include Choriocarcinoma and Pancreas Adenocarcinoma. Among its related pathways are Metabolism and E2F transcription factor network.
Entrez Gene ID
6241
UniProt ID
P31350
Alternative Names
R2; RR2; RR2M
Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Biological Process
Biological Process 2'-deoxyribonucleotide biosynthetic processManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process blastocyst developmentIEA:Ensembl
Biological Process deoxyribonucleotide biosynthetic processISS:UniProtKB
Biological Process DNA replicationIEA:UniProtKB-UniPathway
Biological Process positive regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process protein heterotetramerizationIEA:Ensembl
Biological Process ribonucleoside diphosphate metabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Cytoplasm
Nucleus
Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells.
PTM
Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. Phosphorylated on Thr-33 by CDK1 and CDK2; predominantly in G2 and M phase (PubMed:22632967).
Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-RRM2 Antibody (11BA12)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare