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Rabbit Anti-RTRAF Recombinant Antibody (EPR15799) (CBMAB-1786-CN)

This product is a rabbit antibody that recognizes RTRAF of human. The antibody EPR15799 can be used for immunoassay techniques such as: IF, IP, WB, IHC-P.
See all RTRAF antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR15799
Antibody Isotype
IgG
Application
IF, IP, WB, IHC-P

Basic Information

Immunogen
Synthetic peptide within Human C14orf166 aa. 200 to the C-terminus.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
59% PBS, 40% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Concentration
1.051 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RNA Transcription, Translation And Transport Factor
Introduction
RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). This protein may be required for RNA transport (PubMed:24608264). (Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157).
Entrez Gene ID
Human51637
Mouse68045
Rat302247
UniProt ID
HumanQ9Y224
MouseQ9CQE8
RatQ6QI16
Alternative Names
CLE; CLE7; hCLE; CGI99; RLLM1; hCLE1; CGI-99; LCRP369; C14orf166
Function
RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395).
Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230).
May be required for RNA transport (PubMed:24608264).
(Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157).
Biological Process
Biological Process negative regulation of protein kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process RNA transportManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process tRNA splicing, via endonucleolytic cleavage and ligationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Cytoplasm, cytosol
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
May localize at the centrosome during mitosis (PubMed:15147888).
Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264).
Nucleus
Cytoplasm
(Microbial infection) Following influenza A virus (IAV) infection, included in influenza A virions via its association with packaged viral ribonucleoproteins (vRNP) in the nucleus and cytoplasm (PubMed:21900157, PubMed:26864902).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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