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Mouse Anti-S. cerevisiae RAD53 Recombinant Antibody (EL7.E1) (CBMAB-V208-1375-CQ)

This product is a mouse antibody that recognizes S. cerevisiae RAD53. The antibody EL7.E1 can be used for immunoassay techniques such as: WB.
See all S. cerevisiae RAD53 antibodies
Published Data
Fig.1 Whole-cell lysates of logarithmically growing cells were analyzed by Western blotting with Rad53 and RNR1-4 antibodies.
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Summary

Host Animal
Mouse
Specificity
S. cerevisiae
Clone
EL7.E1
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant full length protein corresponding to Rad53. Yeast RAD53 produced as a recombinant protein in E. coli
Specificity
S. cerevisiae
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
serine/threonine/tyrosine protein kinase RAD53
Introduction
Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. Seems to be involved in the phosphorylation of RPH1.
Entrez Gene ID
855950
UniProt ID
P22216
Alternative Names
RAD53; serine/threonine/tyrosine protein kinase RAD53; LSD1; MEC2; SPK1;
Function
Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. Seems to be involved in the phosphorylation of RPH1.
Biological Process
Biological Process deoxyribonucleoside triphosphate biosynthetic processManual Assertion Based On ExperimentIMP:SGD
Biological Process DNA damage checkpoint signalingManual Assertion Based On ExperimentIGI:SGD
Biological Process DNA repairManual Assertion Based On ExperimentIMP:SGD
Biological Process DNA replication initiationManual Assertion Based On ExperimentIMP:SGD
Biological Process mitotic DNA damage checkpoint signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of DNA damage checkpoint1 PublicationIC:ComplexPortal
Biological Process negative regulation of phosphorylationManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of cellular respirationManual Assertion Based On ExperimentIMP:SGD
Biological Process protein localizationManual Assertion Based On ExperimentIMP:SGD
Biological Process regulation of DNA repair1 PublicationIC:ComplexPortal
Cellular Location
Nucleus
PTM
Autophosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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