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Rabbit Anti-S1PR3 (N-terminus) Recombinant Antibody (EPR4540) (CBMAB-E2284-FY)

This product is rabbit antibody that recognizes S1PR3. The antibody EPR4540 can be used for immunoassay techniques such as: WB.
See all S1PR3 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
EPR4540
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
A synthetic peptide corresponding to residues near the N-terminus of human EDG3 was used as an immunogen
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
Sphingosine-1-Phosphate Receptor 3
Introduction
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.
Entrez Gene ID
Human1903
Mouse13610
Rat306792
UniProt ID
HumanQ99500
MouseQ9Z0U9
RatF1M9D3
Alternative Names
Sphingosine-1-Phosphate Receptor 3; Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 3; Endothelial Differentiation G-Protein Coupled Receptor 3; Sphingosine 1-Phosphate Receptor Edg-3; S1P Receptor Edg-3; S1P Receptor 3; EDG3
Function
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Biological Process
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Notch signaling pathwayIEA:Ensembl
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of interleukin-1 beta productionIEA:Ensembl
Biological Process regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-40
Helical: 41-65
Cytoplasmic: 66-72
Helical: 73-101
Extracellular: 102-115
Helical: 116-134
Cytoplasmic: 135-153
Helical: 154-179
Extracellular: 180-195
Helical: 196-216
Cytoplasmic: 217-243
Helical: 244-265
Extracellular: 266-281
Helical: 282-302
Cytoplasmic: 303-378
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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