S1PR3
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
Full Name
Sphingosine-1-Phosphate Receptor 3
Function
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Biological Process
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Notch signaling pathwayIEA:Ensembl
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of interleukin-1 beta productionIEA:Ensembl
Biological Process regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Notch signaling pathwayIEA:Ensembl
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of interleukin-1 beta productionIEA:Ensembl
Biological Process regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-40
Helical: 41-65
Cytoplasmic: 66-72
Helical: 73-101
Extracellular: 102-115
Helical: 116-134
Cytoplasmic: 135-153
Helical: 154-179
Extracellular: 180-195
Helical: 196-216
Cytoplasmic: 217-243
Helical: 244-265
Extracellular: 266-281
Helical: 282-302
Cytoplasmic: 303-378
Helical: 41-65
Cytoplasmic: 66-72
Helical: 73-101
Extracellular: 102-115
Helical: 116-134
Cytoplasmic: 135-153
Helical: 154-179
Extracellular: 180-195
Helical: 196-216
Cytoplasmic: 217-243
Helical: 244-265
Extracellular: 266-281
Helical: 282-302
Cytoplasmic: 303-378
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Anti-S1PR3 antibodies
Products List
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Target: S1PR3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1025
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:5000
Target: S1PR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G11
Application*: IH, E
Target: S1PR3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0099
Application*: WB
Target: S1PR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4617
Application*: E, P
Target: S1PR3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3995
Application*: IH
Target: S1PR3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1938
Application*: F
Target: S1PR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-1625
Application*: E, IH
Target: S1PR3
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBFYE-1624
Application*: WB
Target: S1PR3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-1623
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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