S1PR3

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

Sphingosine-1-Phosphate Receptor 3

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Notch signaling pathwayIEA:Ensembl
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of interleukin-1 beta productionIEA:Ensembl
Biological Process regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cell membrane

Extracellular: 1-40
Helical: 41-65
Cytoplasmic: 66-72
Helical: 73-101
Extracellular: 102-115
Helical: 116-134
Cytoplasmic: 135-153
Helical: 154-179
Extracellular: 180-195
Helical: 196-216
Cytoplasmic: 217-243
Helical: 244-265
Extracellular: 266-281
Helical: 282-302
Cytoplasmic: 303-378