S1PR3

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
Full Name
Sphingosine-1-Phosphate Receptor 3
Function
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Biological Process
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Notch signaling pathwayIEA:Ensembl
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of interleukin-1 beta productionIEA:Ensembl
Biological Process regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-40
Helical: 41-65
Cytoplasmic: 66-72
Helical: 73-101
Extracellular: 102-115
Helical: 116-134
Cytoplasmic: 135-153
Helical: 154-179
Extracellular: 180-195
Helical: 196-216
Cytoplasmic: 217-243
Helical: 244-265
Extracellular: 266-281
Helical: 282-302
Cytoplasmic: 303-378
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Anti-S1PR3 antibodies

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Rabbit Anti-S1PR3 Recombinant Antibody (EG1025) (CBMAB-EN1209-LY)

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Target: S1PR3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1025
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:5000
Datasheet SDS

Mouse Anti-S1PR3 Recombinant Antibody (2G11) (CBMAB-A2451-LY)

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Target: S1PR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G11
Application*: IH, E
Datasheet SDS

Mouse Anti-S1PR3 (C-Term) Recombinant Antibody (CBXS-0099) (CBMAB-S3098-CQ)

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Target: S1PR3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0099
Application*: WB
Datasheet SDS

Mouse Anti-S1PR3 Recombinant Antibody (CBXS-4617) (CBMAB-S1857-CQ)

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Target: S1PR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4617
Application*: E, P
Datasheet SDS

Mouse Anti-S1PR3 Recombinant Antibody (CBXS-3995) (CBMAB-S1256-CQ)

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Target: S1PR3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3995
Application*: IH
Datasheet SDS

Mouse Anti-S1PR3 Recombinant Antibody (CBXS-1938) (CBMAB-S0143-CQ)

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Target: S1PR3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1938
Application*: F
Datasheet SDS

Mouse Anti-S1PR3 (AA 302-378) Recombinant Antibody (CBFYE-1625) (CBMAB-E2286-FY)

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Target: S1PR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-1625
Application*: E, IH
Datasheet SDS

Mouse Anti-S1PR3 (C-terminus) Recombinant Antibody (CBFYE-1624) (CBMAB-E2285-FY)

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Target: S1PR3
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBFYE-1624
Application*: WB
Datasheet SDS

Mouse Anti-S1PR3 Recombinant Antibody (CBFYE-1623) (CBMAB-E2283-FY)

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Target: S1PR3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-1623
Application*: F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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