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Rabbit Anti-SLC17A7 Monoclonal Antibody (EPR10953) (CBMAB-1705-YC)

Provided herein is a rabbit monoclonal antibody against Human SLC17A7. The antibody, clone EPR10953, can be used for immunoassay techniques, such as WB.
See all SLC17A7 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR10953
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human VGluT1 aa 500 to the C-terminus (Cysteine residue).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 17 Member 7
Introduction
SLC17A7 is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport.
Entrez Gene ID
116638
UniProt ID
Q62634
Alternative Names
BNPI; Vglut1
Function
Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226).
At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity).
The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H+-ATPase across the synaptic vesicle membrane (By similarity).
In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity).
Moreover, may function as a K+/H+ antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity).
The vesicular K+/H+ antiport activity is electroneutral (By similarity).
At the plasma membrane, following exocytosis, functions as a symporter of Na+ and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:10820226).
The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity).
Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity).
Biological Process
Biological Process anion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process brain developmentIEA:Ensembl
Biological Process chloride transportISS:UniProtKB
Biological Process ion transportTAS:Reactome
Biological Process L-glutamate transmembrane transportISS:UniProtKB
Biological Process neural retina developmentIEA:Ensembl
Biological Process neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neurotransmitter transportTAS:Reactome
Biological Process phosphate ion homeostasisIEA:Ensembl
Biological Process phosphate ion transportISS:UniProtKB
Biological Process potassium ion transportISS:UniProtKB
Biological Process regulation of synapse structure or activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of synaptic vesicle endocytosisIEA:Ensembl
Biological Process sodium-dependent phosphate transportISS:UniProtKB
Biological Process synaptic transmission, glutamatergicManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cell membrane
Synapse, synaptosome
Topology
Cytoplasmic: 1-63
Helical: 64-84
Extracellular: 85-116
Helical: 117-137
Cytoplasmic: 138-140
Helical: 141-161
Extracellular: 162-169
Helical: 170-190
Cytoplasmic: 191-208
Helical: 209-229
Extracellular: 230-236
Helical: 237-257
Cytoplasmic: 258-302
Helical: 303-323
Extracellular: 324-341
Helical: 342-362
Cytoplasmic: 363-378
Helical: 379-399
Extracellular: 400-401
Helical: 402-422
Cytoplasmic: 423-435
Helical: 436-456
Extracellular: 457-469
Helical: 470-490
Cytoplasmic: 491-560
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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