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Rabbit Anti-STAU1 Monoclonal Antibody (EPR7966) (CBMAB-1564-YC)

Provided herein is a rabbit monoclonal antibody against Human STAU1. The antibody, clone EPR7966, can be used for immunoassay techniques, such as ICC, IF, FC and WB.
See all STAU1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR7966
Antibody Isotype
IgG
Application
ICC, IF, FC, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues in Human Staufen.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
staufen, RNA binding protein, homolog 1 (Drosophila)
Introduction
STAU1 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. STAU1 has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation.
Entrez Gene ID
Human6780
Mouse20853
Rat84496
UniProt ID
HumanO95793
MouseQ9Z108
RatQ66HP4
Alternative Names
STAU; PPP1R150
Function
Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
(Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.
Biological Process
Biological Process anterograde dendritic transport of messenger ribonucleoprotein complexManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to oxidative stressIEA:Ensembl
Biological Process germ cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular mRNA localizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process modification of postsynaptic structureIEA:Ensembl
Biological Process positive regulation by virus of viral protein levels in host cellManual Assertion Based On ExperimentIMP:AgBase
Biological Process positive regulation of long-term synaptic potentiationIEA:Ensembl
Biological Process positive regulation of viral genome replicationManual Assertion Based On ExperimentIMP:AgBase
Biological Process protein localization to synapseManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Rough endoplasmic reticulum
Localizes exclusively with the rough reticulum endoplasmic (RER).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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