STAU1

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq]

Full Name

staufen, RNA binding protein, homolog 1 (Drosophila)

Function

Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
(Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.

Biological Process

Biological Process anterograde dendritic transport of messenger ribonucleoprotein complexManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to oxidative stressIEA:Ensembl
Biological Process germ cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular mRNA localizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process modification of postsynaptic structureIEA:Ensembl
Biological Process positive regulation by virus of viral protein levels in host cellManual Assertion Based On ExperimentIMP:AgBase
Biological Process positive regulation of long-term synaptic potentiationIEA:Ensembl
Biological Process positive regulation of viral genome replicationManual Assertion Based On ExperimentIMP:AgBase
Biological Process protein localization to synapseManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Rough endoplasmic reticulum
Localizes exclusively with the rough reticulum endoplasmic (RER).