Mouse Anti-SULT2B1 Recombinant Antibody (CBXS-1118) (CBMAB-S4002-CQ)

Name: Mouse Anti-SULT2B1 Recombinant Antibody (CBXS-1118)
SKU: CBMAB-S4002-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-1118

Application

ELISA(Cap)

Immunogen

Recombinant Human SULT2B1 Protein

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

sulfotransferase family, cytosolic, 2B, member 1

Introduction

Sulfotransferasefamily cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1,Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2,is a cytoplasm protein which belongs to the sulfotransferase 1 family. Thehuman hydroxysteroid sulfotransferase (SULT) family is comprised of twosubfamilies, SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta,prostate and trachea. A lesser expression of SULT1B1 was observed in the smallintestine and lung. SULT2B1 catalyzes the sulfate conjugation of many hormones,neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases thewater solubility of most compounds, and therefore their renal excretion, but itcan also result in bioactivation to form active metabolites. SULT2B1 sulfateshydroxysteroids like DHEA. Isoform 1 preferentially sulfonatescholesterol. The two SULT2B1 isoforms, SULT2B1a and SULT2B1b, are encoded by asingle gene as a result of alternative transcription initiation and alternativesplicing. SULT2B1b catalyzes the sulfonation of 3beta-hydroxysteroid hormonesand cholesterol, whereas SULT2B1a preferentially catalyzes pregnenolonesulfonation.

Entrez Gene ID

6820

UniProt ID

O00204

Alternative Names

HSST2

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:19589875, PubMed:12145317).
Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:9799594, PubMed:12145317, PubMed:21855633, PubMed:16855051).
Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633).
Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).
Isoform 2
Sulfonates pregnenolone but not cholesterol.

Biological Process

Biological Process 3'-phosphoadenosine 5'-phosphosulfate metabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process cholesterol metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of epidermal cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process steroid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sulfationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytosol
Microsome
Nucleus
Phosphorylation of Ser-348 is required for translocation to the nucleus.

Involvement in disease

Ichthyosis, congenital, autosomal recessive 14 (ARCI14):
A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.

PTM

Phosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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