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Rabbit Anti-SYNGAP1 Monoclonal Antibody (EPR2883Y) (CBMAB-1603-YC)

Provided herein is a rabbit monoclonal antibody against Human SYNGAP1. The antibody, clone EPR2883Y, can be used for immunoassay techniques, such as FC, ICC, IF and WB.
See all SYNGAP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR2883Y
Antibody Isotype
IgG
Application
FC, ICC, IF, WB

Basic Information

Immunogen
A synthetic peptide corresponding to residues on the C terminus of human SynGAP
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
synaptic Ras GTPase activating protein 1
Introduction
SYNGAP1 is a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. SYNGAP1 negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis.
Entrez Gene ID
Human8831
Mouse240057
Rat192117
UniProt ID
HumanQ96PV0
MouseF6SEU4
RatQ9QUH6
Alternative Names
MRD5; RASA1; RASA5; SYNGAP
Function
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).
Biological Process
Biological Process axonogenesisIEA:Ensembl
Biological Process dendrite developmentIEA:Ensembl
Biological Process maintenance of postsynaptic specialization structureIEA:Ensembl
Biological Process negative regulation of axonogenesisIEA:Ensembl
Biological Process negative regulation of neuron apoptotic processIEA:Ensembl
Biological Process negative regulation of Ras protein signal transductionISS:UniProtKB
Biological Process neuron apoptotic processIEA:Ensembl
Biological Process pattern specification processIEA:Ensembl
Biological Process Ras protein signal transductionIEA:Ensembl
Biological Process receptor clusteringIEA:Ensembl
Biological Process regulation of GTPase activityIEA:InterPro
Biological Process regulation of long-term neuronal synaptic plasticityIEA:Ensembl
Biological Process regulation of MAPK cascadeIEA:Ensembl
Biological Process regulation of synapse structure or activityIEA:Ensembl
Biological Process regulation of synaptic plasticityISS:UniProtKB
Biological Process visual learningIEA:Ensembl
Cellular Location
cytosol
dendritic shaft
glutamatergic synapse
plasma membrane
postsynaptic density
Involvement in disease
Intellectual developmental disorder, autosomal dominant 5 (MRD5):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD5 patients show global developmental delay with delayed motor development, hypotonia, moderate-to-severe intellectual disability, and severe language impairment. Epilepsy and autism can be present in some patients.
PTM
Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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