Rabbit Anti-SYNGAP1 Recombinant Antibody (CBXS-5359) (CBMAB-S2572-CQ)

Name: Rabbit Anti-SYNGAP1 Recombinant Antibody (CBXS-5359)
SKU: CBMAB-S2572-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-5359

Application

WB, IP

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

synaptic Ras GTPase activating protein 1

Introduction

The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5).

Entrez Gene ID

Human	8831
Mouse	240057
Rat	192117

UniProt ID

Human	Q96PV0
Mouse	F6SEU4
Rat	Q9QUH6

Alternative Names

MRD5; RASA1; RASA5; SYNGAP

Function

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).

Biological Process

Biological Process axonogenesisIEA:Ensembl
Biological Process dendrite developmentIEA:Ensembl
Biological Process maintenance of postsynaptic specialization structureIEA:Ensembl
Biological Process negative regulation of axonogenesisIEA:Ensembl
Biological Process negative regulation of neuron apoptotic processIEA:Ensembl
Biological Process negative regulation of Ras protein signal transductionISS:UniProtKB
Biological Process neuron apoptotic processIEA:Ensembl
Biological Process pattern specification processIEA:Ensembl
Biological Process Ras protein signal transductionIEA:Ensembl
Biological Process receptor clusteringIEA:Ensembl
Biological Process regulation of GTPase activityIEA:InterPro
Biological Process regulation of long-term neuronal synaptic plasticityIEA:Ensembl
Biological Process regulation of MAPK cascadeIEA:Ensembl
Biological Process regulation of synapse structure or activityIEA:Ensembl
Biological Process regulation of synaptic plasticityISS:UniProtKB
Biological Process visual learningIEA:Ensembl

Cellular Location

cytosol
dendritic shaft
glutamatergic synapse
plasma membrane
postsynaptic density

Involvement in disease

Intellectual developmental disorder, autosomal dominant 5 (MRD5):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD5 patients show global developmental delay with delayed motor development, hypotonia, moderate-to-severe intellectual disability, and severe language impairment. Epilepsy and autism can be present in some patients.

PTM

Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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