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Mouse Anti-TMPRSS3 Recombinant Antibody (CBYJT-3564) (CBMAB-T2891-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3564
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa119-215 from human TMPRSS3 (NP_076927) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 119-215

Target

Full Name
transmembrane protease, serine 3
Introduction
TMPRSS3 is a protein that belongs to the serine protease family. TMPRSS3 contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. TMPRSS3 was identified by its association with both congenital and childhood onset autosomal recessive deafness. TMPRSS3 is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. TMPRSS3 was also identified as a tumor-associated gene that is overexpressed in ovarian tumors.
Entrez Gene ID
64699
UniProt ID
P57727
Alternative Names
Transmembrane Protease, Serine 3; Tumor-Associated Differentially-Expressed Gene 12 Protein; Serine Protease TADG-12; ECHOS1; TADG12; Transmembrane Protease Serine 3
Function
Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity).
Activates ENaC (in vitro).
Biological Process
Biological Process cellular sodium ion homeostasisSource:MGI1 Publication
Biological Process proteolysisSource:UniProtKB1 Publication
Biological Process sensory perception of soundSource:Ensembl
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Deafness, autosomal recessive, 8 (DFNB8):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Cytoplasmic: 1-48
Helical: 49-69
Extracellular: 70-454
PTM
Undergoes autoproteolytic activation.
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For research use only. Not intended for any clinical use.

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