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Mouse Anti-TMPRSS3 Recombinant Antibody (2E1) (CBMAB-A9224-LY)

The product is antibody recognizes TMPRSS3. The antibody 2E1 immunoassay techniques such as: WB, ELISA.
See all TMPRSS3 antibodies
Published Data
Fig.1 Immunohistochemical (IHC) and H&E staining of TMPRSS3 and TNFRSF11B in breast cancer.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TMPRSS3 (NP_076927, 119 a.a. ~ 214 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
transmembrane protease, serine 3
Introduction
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq]
Entrez Gene ID
64699
UniProt ID
P57727
Alternative Names
DFNB10; DFNB8; ECHOS1; TADG12
Function
Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity).
Activates ENaC (in vitro).
Biological Process
Biological Process cellular sodium ion homeostasisSource:MGI1 Publication
Biological Process proteolysisSource:UniProtKB1 Publication
Biological Process sensory perception of soundSource:Ensembl
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Deafness, autosomal recessive, 8 (DFNB8):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Cytoplasmic: 1-48
Helical: 49-69
Extracellular: 70-454
PTM
Undergoes autoproteolytic activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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