Mouse Anti-TMPRSS3 Recombinant Antibody (CBYJT-3566) (CBMAB-T2893-YJ)

Name: Mouse Anti-TMPRSS3 Recombinant Antibody (CBYJT-3566)
SKU: CBMAB-T2893-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3566

Application

ELISA, WB

Immunogen

Recombinant protein corresponding to aa 221-317 of human TMPRSS3

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 10% Glycerol

Preservative

0.05% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 221-317

More Infomation

Target

Full Name

transmembrane protease, serine 3

Introduction

TMPRSS3 is a protein that belongs to the serine protease family. TMPRSS3 contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. TMPRSS3 was identified by its association with both congenital and childhood onset autosomal recessive deafness. TMPRSS3 is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. TMPRSS3 was also identified as a tumor-associated gene that is overexpressed in ovarian tumors.

Entrez Gene ID

64699

UniProt ID

P57727

Alternative Names

Transmembrane Protease, Serine 3; Tumor-Associated Differentially-Expressed Gene 12 Protein; Serine Protease TADG-12; ECHOS1; TADG12; Transmembrane Protease Serine 3

Function

Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity).
Activates ENaC (in vitro).

Biological Process

Biological Process cellular sodium ion homeostasisSource:MGI1 Publication
Biological Process proteolysisSource:UniProtKB1 Publication
Biological Process sensory perception of soundSource:Ensembl

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Deafness, autosomal recessive, 8 (DFNB8):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Topology

Cytoplasmic: 1-48
Helical: 49-69
Extracellular: 70-454

PTM

Undergoes autoproteolytic activation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-TMPRSS3 Recombinant Antibody (CBYJT-3564) (CAT#: CBMAB-T2891-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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