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Mouse Anti-EIPR1 Recombinant Antibody (2H5) (CBMAB-A9588-LY)

The product is antibody recognizes TSSC1. The antibody 2H5 immunoassay techniques such as: WB, ELISA.
See all EIPR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
2H5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TSSC1 (NP_003301, 288 a.a. ~ 387 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
EARP Complex And GARP Complex Interacting Protein 1
Introduction
This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq]
Entrez Gene ID
Human7260
Rat362721
UniProt ID
HumanQ53HC9
RatQ5PPK9
Research Area
Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922).

Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein(PubMed:27440922).

Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922).

Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity).

Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity).
Biological Process
Endocytic recycling Source: UniProtKB
Positive regulation of endocytic recycling Source: UniProtKB
Positive regulation of retrograde transport, endosome to Golgi Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of insulin secretion Source: UniProtKB
Cellular Location
Trans-Golgi network
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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