Sign in or Register   Sign in or Register
  |  

Mouse Anti-TXNRD2 Recombinant Antibody (CBYJT-5496) (CBMAB-T5112-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TXNRD2 (Thioredoxin Reductase 2). The antibody can be used for immunoassay techniques, such as WB, IP.
See all TXNRD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5496
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TXNRD2 Gene(Protein Coding) Thioredoxin Reductase 2
Introduction
TXNRD2 belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. TXNRD2 is a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It plays a role as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
Entrez Gene ID
10587
UniProt ID
Q9NNW7
Alternative Names
Thioredoxin Reductase 2; Selenoprotein Z; Thioredoxin Reductase Beta; Thioredoxin Reductase TR3; EC 1.8.1.9; TR-BETA; TRXR2; SELZ
Function
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690).
Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
Biological Process
Biological Process cell redox homeostasis Source:UniProtKB1 Publication
Biological Process response to hyperoxia Source:Ensembl
Biological Process response to oxygen radical Source:UniProtKB1 Publication
Biological Process response to selenium ion Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Cellular Location
Mitochondrion
Involvement in disease
Glucocorticoid deficiency 5 (GCCD5):
A form of glucocorticoid deficiency, a rare autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TXNRD2 Recombinant Antibody (CBYJT-5496)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare