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Mouse Anti-SUN1 Recombinant Antibody (2D10) (CBMAB-A9798-LY)

The product is antibody recognizes UNC84A. The antibody 2D10 immunoassay techniques such as: WB, ELISA.
See all SUN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
UNC84A (AAH13613, 1 a.a. ~ 257 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Sad1 and UNC84 domain containing 1
Introduction
This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined. [provided by RefSeq]
Entrez Gene ID
23353
UniProt ID
O94901
Alternative Names
FLJ12407; KIAA0810; MGC176649; SUN1
Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275).
The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity).
Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity).
Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity).
Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity).
Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity).
Required for efficient localization of SYNE4 in the nuclear envelope (By similarity).
May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity).
May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709).
Biological Process
Biological Process centrosome localizationIEA:Ensembl
Biological Process homologous chromosome pairing at meiosisIEA:Ensembl
Biological Process meiotic attachment of telomere to nuclear envelopeIEA:Ensembl
Biological Process nuclear envelope organizationManual Assertion Based On ExperimentIGI:MGI
Biological Process nuclear matrix anchoring at nuclear membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nucleokinesis involved in cell motility in cerebral cortex radial glia guided migrationIEA:Ensembl
Biological Process spermatogenesisIEA:UniProtKB-KW
Cellular Location
Nucleus inner membrane
At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles.
Topology
Nuclear: 1-288
Helical: 289-308
Perinuclear space: 309-785
PTM
The disulfide bond with KASH domain-containing nesprins is required for stability of the respective LINC complexes under tensile forces.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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