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Recombinant Mouse Anti-SUN1 Recombinant Antibody (12.10F) (CBMAB-XB1076-YC)

Provided herein is a Mouse Recombinant Antibody against Sad1 And UNC84 Domain Containing 1. The antibody can be used for immunoassay techniques, such as IF, WB.
See all SUN1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
12.10F
Antibody Isotype
IgG2a, κ
Application
IF, WB

Basic Information

Immunogen
GST fused to residues encoded by exons 6, 8, 10
Specificity
Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sad1 and UNC84 domain containing 1
Introduction
SUN1 (Sad1 And UNC84 Domain Containing 1) is a protein coding gene. Diseases associated with SUN1 include Emery-Dreifuss Muscular Dystrophy and Muscular Dystrophy. Among its related pathways are Cell Cycle, Mitotic and Meiosis. Gene Ontology annotations related to this gene include lamin binding. An important paralog of this gene isSUN2.
Entrez Gene ID
Mouse77053
Rat360773
UniProt ID
MouseQ9D666
RatQ5U2W0
Alternative Names
SUN Domain-Containing Protein 1; Unc-84 Homolog A
Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275).
The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity).
Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity).
Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity).
Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity).
Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity).
Required for efficient localization of SYNE4 in the nuclear envelope (By similarity).
May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity).
May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709).
Biological Process
Biological Process centrosome localizationIEA:Ensembl
Biological Process homologous chromosome pairing at meiosisIEA:Ensembl
Biological Process meiotic attachment of telomere to nuclear envelopeIEA:Ensembl
Biological Process nuclear envelope organizationManual Assertion Based On ExperimentIGI:MGI
Biological Process nuclear matrix anchoring at nuclear membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nucleokinesis involved in cell motility in cerebral cortex radial glia guided migrationIEA:Ensembl
Biological Process spermatogenesisIEA:UniProtKB-KW
Cellular Location
Nucleus inner membrane
At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles.
Topology
Nuclear: 1-288
Helical: 289-308
Perinuclear space: 309-785
PTM
The disulfide bond with KASH domain-containing nesprins is required for stability of the respective LINC complexes under tensile forces.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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