Mouse Anti-SUN1 Recombinant Antibody (CBXS-4475) (CBMAB-S1717-CQ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity).
Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity).
Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity).
Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity).
Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity).
Required for efficient localization of SYNE4 in the nuclear envelope (By similarity).
May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity).
May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709).
Biological Process homologous chromosome pairing at meiosisIEA:Ensembl
Biological Process meiotic attachment of telomere to nuclear envelopeIEA:Ensembl
Biological Process nuclear envelope organizationManual Assertion Based On ExperimentIGI:MGI
Biological Process nuclear matrix anchoring at nuclear membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nucleokinesis involved in cell motility in cerebral cortex radial glia guided migrationIEA:Ensembl
Biological Process spermatogenesisIEA:UniProtKB-KW
At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles.
Helical: 289-308
Perinuclear space: 309-785
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
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Mouse Anti-SUN1 Recombinant Antibody (2D10) (CAT#: CBMAB-A9798-LY)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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