AIF1

This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain.

Full Name

Allograft Inflammatory Factor 1

Alternative Names

Allograft Inflammatory Factor 1; Ionized Calcium-Binding Adapter Molecule 1; Interferon Gamma Responsive Transcript; Protein G1; AIF-1; IBA1; IRT-1; IRT1; G1;

Function

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Biological Process

Actin crosslink formation Source: ARUK-UCL
Actin filament bundle assembly Source: UniProtKB
Actin filament polymerization Source: UniProtKB
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to oxidative stress Source: ARUK-UCL
Inflammatory response Source: UniProtKB
Microglial cell activation Source: UniProtKB
Negative regulation of smooth muscle cell chemotaxis Source: UniProtKB
Negative regulation of smooth muscle cell proliferation Source: UniProtKB
Parallel actin filament bundle assembly Source: ARUK-UCL
Phagocytosis, engulfment Source: UniProtKB
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of chemokine production Source: ARUK-UCL
Positive regulation of chemotaxis Source: ARUK-UCL
Positive regulation of fibroblast growth factor production Source: ARUK-UCL
Positive regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Positive regulation of interleukin-6 production Source: ARUK-UCL
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of mononuclear cell migration Source: ARUK-UCL
Positive regulation of smooth muscle cell chemotaxis Source: UniProtKB
Positive regulation of smooth muscle cell proliferation Source: UniProtKB
Positive regulation of T cell migration Source: UniProtKB
Positive regulation of T cell proliferation Source: UniProtKB
Rac protein signal transduction Source: UniProtKB
Regulation of gene expression Source: ARUK-UCL
Ruffle assembly Source: UniProtKB

Cellular Location

Ruffle membrane; Cytoplasmic side; Cytoskeleton; Phagocytic cup. Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

PTM

Phosphorylated on serine residues.