AIF1

This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain.
Full Name
Allograft Inflammatory Factor 1
Alternative Names
Allograft Inflammatory Factor 1; Ionized Calcium-Binding Adapter Molecule 1; Interferon Gamma Responsive Transcript; Protein G1; AIF-1; IBA1; IRT-1; IRT1; G1;
Function
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Biological Process
Actin crosslink formation Source: ARUK-UCL
Actin filament bundle assembly Source: UniProtKB
Actin filament polymerization Source: UniProtKB
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to oxidative stress Source: ARUK-UCL
Inflammatory response Source: UniProtKB
Microglial cell activation Source: UniProtKB
Negative regulation of smooth muscle cell chemotaxis Source: UniProtKB
Negative regulation of smooth muscle cell proliferation Source: UniProtKB
Parallel actin filament bundle assembly Source: ARUK-UCL
Phagocytosis, engulfment Source: UniProtKB
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of chemokine production Source: ARUK-UCL
Positive regulation of chemotaxis Source: ARUK-UCL
Positive regulation of fibroblast growth factor production Source: ARUK-UCL
Positive regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Positive regulation of interleukin-6 production Source: ARUK-UCL
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of mononuclear cell migration Source: ARUK-UCL
Positive regulation of smooth muscle cell chemotaxis Source: UniProtKB
Positive regulation of smooth muscle cell proliferation Source: UniProtKB
Positive regulation of T cell migration Source: UniProtKB
Positive regulation of T cell proliferation Source: UniProtKB
Rac protein signal transduction Source: UniProtKB
Regulation of gene expression Source: ARUK-UCL
Ruffle assembly Source: UniProtKB
Cellular Location
Ruffle membrane; Cytoplasmic side; Cytoskeleton; Phagocytic cup. Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
PTM
Phosphorylated on serine residues.
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Anti-AIF1 antibodies

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Mouse Anti-AIF1 Recombinant Antibody (EC10) (V2LY-0624-LY10)

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Target: AIF1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: EC10
Application*: IH
Datasheet SDS

Mouse Anti-AIF1 Recombinant Antibody (V2-634182) (CBMAB-AP223LY)

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Target: AIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-634182
Application*: IHC
Datasheet SDS

Rabbit Anti-AIF1 Recombinant Antibody (V2-629848) (CBMAB-Hb011-LY)

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Target: AIF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-629848
Application*: E, IF(ICC), P
Datasheet SDS

Mouse Anti-AIF1 Recombinant Antibody (V2-606575) (CBMAB-X0228-FY)

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Target: AIF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-606575
Application*: P, FC
Datasheet SDS

Rabbit Anti-AIF1 Recombinant Antibody (V2-266302) (CBMAB-I1284-YY)

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Target: AIF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: V2-266302
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-AIF1 Recombinant Antibody (V2-180339) (CBMAB-A1799-YC)

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Target: AIF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-180339
Application*: ELISA
Datasheet SDS

Mouse Anti-AIF1 Recombinant Antibody (V2-12547) (CBMAB-1037-CN)

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Target: AIF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: V2-12547
Application*: IF, P, WB
Datasheet SDS

Human AIF1 ELISA Kit (V2LY-0626-LY4329)

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Target: AIF1
Sensitivity: 1.39 ng/mL
Detection Range: 3-900 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rat Aif1 ELISA Kit (V2LY-0626-LY2044)

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Target: Aif1
Sensitivity: 0.0072 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Mouse Aif1 ELISA Kit (V2LY-0626-LY2008)

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Target: Aif1
Sensitivity: 0.0077 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Human Recombinant AIF1 protein, His Tag (V2LY-0526-LY4618)

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Target: AIF1
Expressed Host: E. coli
Sequence: Amino Acid: 1-147
Tag: His Tag
Datasheet SDS

Mouse Anti-AIF1 Recombinant Antibody (V2-12546) (CBMAB-1036-CN)

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Target: AIF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-12546
Application*: WB, E
Datasheet SDS

Mouse Anti-AIF1 Recombinant Antibody (V2-12545) (CBMAB-1035-CN)

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Target: AIF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-12545
Application*: IH
Datasheet SDS

Mouse Anti-AIF1 Recombinant Antibody (V2-12544) (CBMAB-1034-CN)

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Target: AIF1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: V2-12544
Application*: WB, E, IP, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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