AIP

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Full Name

aryl hydrocarbon receptor interacting protein

Function

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Cellular negative regulator of the hepatitis B virus (HBV) X protein.

Biological Process

Interleukin-12-mediated signaling pathway Source: Reactome
Negative regulation of cyclic-nucleotide phosphodiesterase activity Source: Ensembl
Protein maturation by protein folding Source: HGNC-UCL
Protein targeting to mitochondrion Source: HGNC-UCL
Regulation of protein kinase A signaling Source: Ensembl
Xenobiotic metabolic process Source: Reactome

Cellular Location

Cytoplasm

Involvement in disease

Pituitary adenoma 1, multiple types (PITA1): A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete: growth hormone (GH)-secreting, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid- stimulating hormone (TSH)-secreting, and plurihormonal (GH and TSH) tumors. Familial and sporadic forms have been reported.
Prolactin-secreting pituitary adenoma (PSPA): Most common type of hormonally active pituitary adenoma.