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Mouse Anti-AIP Recombinant Antibody (V2-12551) (CBMAB-1041-CN)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
V2-12551
Application
WB, ELISA
Immunogen
AIP (NP_003968.1, aa. 156-249) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
aryl hydrocarbon receptor interacting protein
Introduction
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus.
The protein may play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Cellular negative regulator of the hepatitis B virus (HBV) X protein.
Entrez Gene ID
9049
UniProt ID
O00170
Alternative Names
ARA9; XAP2; PITA1; XAP-2; FKBP16; FKBP37; SMTPHN
Function
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Cellular negative regulator of the hepatitis B virus (HBV) X protein.
Biological Process
Interleukin-12-mediated signaling pathway Source: Reactome
Negative regulation of cyclic-nucleotide phosphodiesterase activity Source: Ensembl
Protein maturation by protein folding Source: HGNC-UCL
Protein targeting to mitochondrion Source: HGNC-UCL
Regulation of protein kinase A signaling Source: Ensembl
Xenobiotic metabolic process Source: Reactome
Cellular Location
Cytoplasm
Involvement in disease
Pituitary adenoma 1, multiple types (PITA1): A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete: growth hormone (GH)-secreting, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid- stimulating hormone (TSH)-secreting, and plurihormonal (GH and TSH) tumors. Familial and sporadic forms have been reported.
Prolactin-secreting pituitary adenoma (PSPA): Most common type of hormonally active pituitary adenoma.

Fernández-Aceñero, M. J., Barderas, R., García, A. P., Martínez-Useros, J., Díez-Valladares, L., Medina, L. O., ... & Galindo, C. (2021). Aryl hydrocarbon receptor interacting protein (AIP) significantly influences prognosis of pancreatic carcinoma. Annals of Diagnostic Pathology, 53, 151742.

Gunin, A. G., & Golubtzova, N. N. (2021). Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Human Dermis with Aging. Advances in Gerontology, 11(1), 59-63.

Feola, T., Capelli, R., Gianno, F., Compagnoni, C., Letizia, C., De Toma, G., ... & Marie-Lise, J. R. (2021, May). Aryl hydrocarbon receptor Interacting Protein (AIP) status in a functional adrenal adenoma occurring in a patient with a germline AIP mutation. In Endocrine Abstracts (Vol. 73). Bioscientifica.

Del Arco, C. D., Muñoz, L. E., Manchado, R. B., García, A. P., Medina, L. O., Roldán, E. M., ... & Aceñero, M. J. F. (2020). Prognostic Role of Aryl Hydrocarbon Receptor Interacting Protein (AIP) Immunohistochemical Expression in Patients with Resected Gastric Carcinomas. Pathology & Oncology Research, 26(4), 2641-2650.

Cai, F., Hong, Y., Xu, J., Wu, Q., Reis, C., Yan, W., ... & Zhang, J. (2019). A novel mutation of Aryl hydrocarbon receptor interacting protein gene associated with familial isolated pituitary adenoma mediates tumor invasion and growth hormone hypersecretion. World neurosurgery, 123, e45-e59.

Sun, D., Stopka-Farooqui, U., Barry, S., Aksoy, E., Parsonage, G., Vossenkämper, A., ... & Haworth, O. (2019). Aryl hydrocarbon receptor interacting protein maintains germinal center B cells through suppression of BCL6 degradation. Cell reports, 27(5), 1461-1471.

Stojanovic, M., Wu, Z., Stiles, C. E., Miljic, D., Soldatovic, I., Pekic, S., ... & Korbonits, M. (2019). Circulating aryl hydrocarbon receptor-interacting protein (AIP) is independent of GH secretion. Endocrine connections, 8(4), 326-337.

Ozkaya, H. M., Comunoglu, N., Sayitoglu, M., Keskin, F. E., Firtina, S., Khodzhaev, K., ... & Kadioglu, P. (2018). Germline mutations of aryl hydrocarbon receptor-interacting protein (AIP) gene and somatostatin receptor 1–5 and AIP immunostaining in patients with sporadic acromegaly with poor versus good response to somatostatin analogues. Pituitary, 21(4), 335-346.

Hernández-Ramírez, L. C., Trivellin, G., & Stratakis, C. A. (2017). Role of phosphodiesterases on the function of aryl hydrocarbon receptor-interacting protein (AIP) in the pituitary gland and on the evaluation of AIP gene variants. Hormone and Metabolic Research, 49(04), 286-295.

Formosa, R., & Vassallo, J. (2017). Aryl hydrocarbon receptor–interacting protein (AIP) N-terminus gene mutations identified in pituitary adenoma patients alter protein stability and function. Hormones and Cancer, 8(3), 174-184.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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